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Uncovering the source of mitochondrial superoxide in pro-inflammatory macrophages: Insights from immunometabolism (Record no. 1015)

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Personal name Casey, Alva M.
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9 (RLIN) 3172
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Title Uncovering the source of mitochondrial superoxide in pro-inflammatory macrophages: Insights from immunometabolism
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Date of publication, distribution, etc. 2022-10-01.
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General note /pmc/articles/PMC7614207/
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General note /pubmed/35792320
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Summary, etc. Mitochondrial-derived reactive oxygen species are important as antimicrobial agents and redox signals in pro-inflammatory macrophages. Macrophages produce superoxide in response to the TLR4 ligand LPS. However, the mechanism of LPS-induced superoxide generation is not fully understood. Superoxide is produced at complex I and complex III of the electron transport chain. Production of superoxide at either of these sites is highly dependent on the metabolic state of the cell which is dramatically altered by TLR4-induced metabolic reprogramming. This review will outline how metabolism impacts superoxide production in LPS-activated macrophages downstream of TLR4 signalling and address outstanding questions in this field.
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Terms governing use and reproduction
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Terms governing use and reproduction https://creativecommons.org/licenses/by/4.0/This work is licensed under a CC BY 4.0 (https://creativecommons.org/licenses/by/4.0/) International license.
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Language note en
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Topical term or geographic name as entry element Article
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Personal name Murphy, Michael P.
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9 (RLIN) 3173
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Note Biochim Biophys Acta Mol Basis Dis
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Uniform Resource Identifier <a href="http://dx.doi.org/10.1016/j.bbadis.2022.166481">http://dx.doi.org/10.1016/j.bbadis.2022.166481</a>
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