Mesp1 controls the chromatin and enhancer landscapes essential for spatiotemporal patterning of early cardiovascular progenitors (Record no. 1579)
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042 ## - AUTHENTICATION CODE | |
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Authentication code | dc |
100 10 - MAIN ENTRY--PERSONAL NAME | |
Personal name | Lin, Xionghui |
Relator term | author |
9 (RLIN) | 1154 |
245 00 - TITLE STATEMENT | |
Title | Mesp1 controls the chromatin and enhancer landscapes essential for spatiotemporal patterning of early cardiovascular progenitors |
260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
Date of publication, distribution, etc. | 2022-07-01. |
500 ## - GENERAL NOTE | |
General note | /pmc/articles/PMC7613098/ |
500 ## - GENERAL NOTE | |
General note | /pubmed/35817961 |
520 ## - SUMMARY, ETC. | |
Summary, etc. | The mammalian heart arises from various populations of Mesp1-expressing cardiovascular progenitors (CPs) that are specified during the early stages of gastrulation. Mesp1 is a transcription factor (TF) that acts as a master regulator of CP specification and differentiation. However, how Mesp1 regulates the chromatin landscape of nascent mesodermal cells to define the temporal and spatial patterning of the distinct populations of CPs remains unknown. Here, by combining ChIP-seq, RNA-seq and ATAC-seq during mouse pluripotent stem cell differentiation, we defined the dynamic remodelling of the chromatin landscape mediated by Mesp1. We identified different enhancers that are temporally regulated to erase the pluripotent state and specify the pools of CPs that mediate heart development. We identified Zic2 and Zic3 as essential cofactors that act with Mesp1 to regulate its TF activity at key mesodermal enhancers, thereby regulating the chromatin remodelling and gene expression associated with the specification of the different populations of CPs in vivo. Our study identifies the dynamics of the chromatin landscape and enhancer remodelling associated with temporal patterning of early mesodermal cells into the distinct populations of CPs that mediate heart development. |
540 ## - TERMS GOVERNING USE AND REPRODUCTION NOTE | |
Terms governing use and reproduction | |
540 ## - TERMS GOVERNING USE AND REPRODUCTION NOTE | |
Terms governing use and reproduction | https://www.springernature.com/gp/open-research/policies/accepted-manuscript-termsUsers may view, print, copy, and download text and data-mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use: https://www.springernature.com/gp/open-research/policies/accepted-manuscript-terms. |
546 ## - LANGUAGE NOTE | |
Language note | en |
690 ## - LOCAL SUBJECT ADDED ENTRY--TOPICAL TERM (OCLC, RLIN) | |
Topical term or geographic name as entry element | Article |
655 7# - INDEX TERM--GENRE/FORM | |
Genre/form data or focus term | Text |
Source of term | local |
700 10 - ADDED ENTRY--PERSONAL NAME | |
Personal name | Swedlund, Benjamin |
Relator term | author |
9 (RLIN) | 1155 |
700 10 - ADDED ENTRY--PERSONAL NAME | |
Personal name | Ton, Mai-Linh N. |
Relator term | author |
9 (RLIN) | 1156 |
700 10 - ADDED ENTRY--PERSONAL NAME | |
Personal name | Ghazanfar, Shila |
Relator term | author |
9 (RLIN) | 1157 |
700 10 - ADDED ENTRY--PERSONAL NAME | |
Personal name | Guibentif, Carolina |
Relator term | author |
9 (RLIN) | 1158 |
700 10 - ADDED ENTRY--PERSONAL NAME | |
Personal name | Paulissen, Catherine |
Relator term | author |
9 (RLIN) | 1159 |
700 10 - ADDED ENTRY--PERSONAL NAME | |
Personal name | Baudelet, Elodie |
Relator term | author |
9 (RLIN) | 1160 |
700 10 - ADDED ENTRY--PERSONAL NAME | |
Personal name | Plaindoux, Elise |
Relator term | author |
9 (RLIN) | 1161 |
700 10 - ADDED ENTRY--PERSONAL NAME | |
Personal name | Achouri, Younes |
Relator term | author |
9 (RLIN) | 1162 |
700 10 - ADDED ENTRY--PERSONAL NAME | |
Personal name | Calonne, Emilie |
Relator term | author |
9 (RLIN) | 1163 |
700 10 - ADDED ENTRY--PERSONAL NAME | |
Personal name | Dubois, Christine |
Relator term | author |
9 (RLIN) | 1164 |
700 10 - ADDED ENTRY--PERSONAL NAME | |
Personal name | Mansfield, William |
Relator term | author |
9 (RLIN) | 1165 |
700 10 - ADDED ENTRY--PERSONAL NAME | |
Personal name | Zaffran, Stéphane |
Relator term | author |
9 (RLIN) | 1166 |
700 10 - ADDED ENTRY--PERSONAL NAME | |
Personal name | Marioni, John C. |
Relator term | author |
9 (RLIN) | 1167 |
700 10 - ADDED ENTRY--PERSONAL NAME | |
Personal name | Fuks, Francois |
Relator term | author |
9 (RLIN) | 1168 |
700 10 - ADDED ENTRY--PERSONAL NAME | |
Personal name | Göttgens, Berthold |
Relator term | author |
9 (RLIN) | 1169 |
700 10 - ADDED ENTRY--PERSONAL NAME | |
Personal name | Lescroart, Fabienne |
Relator term | author |
9 (RLIN) | 1170 |
700 10 - ADDED ENTRY--PERSONAL NAME | |
Personal name | Blanpain, Cédric |
Relator term | author |
9 (RLIN) | 1171 |
786 0# - DATA SOURCE ENTRY | |
Note | Nat Cell Biol |
856 41 - ELECTRONIC LOCATION AND ACCESS | |
Uniform Resource Identifier | <a href="http://dx.doi.org/10.1038/s41556-022-00947-3">http://dx.doi.org/10.1038/s41556-022-00947-3</a> |
Public note | Connect to this object online. |
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