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Anxiety disorders and age-related changes in physiology (Record no. 1644)

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Personal name Mutz, Julian
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Title Anxiety disorders and age-related changes in physiology
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Date of publication, distribution, etc. 2022-09.
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General note /pmc/articles/PMC7613411/
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General note /pubmed/35048844
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Summary, etc. BACKGROUND: Anxiety disorders are leading contributors to the global disease burden, highly prevalent across the lifespan, and associated with substantially increased morbidity and early mortality. AIMS: The aim of this study was to examine age-related changes across a wide range of physiological measures in middle-aged and older adults with a lifetime history of anxiety disorders compared to healthy controls. METHOD: The UK Biobank study recruited >500,000 adults, aged 37-73, between 2006-2010. We used generalised additive models to estimate non-linear associations between age and hand-grip strength, cardiovascular function, body composition, lung function and heel bone mineral density in cases and in controls. RESULTS: The main dataset included 332,078 adults (mean age = 56.37 years; 52.65% females). In both sexes, individuals with anxiety disorders had a lower hand-grip strength and blood pressure, while their pulse rate and body composition measures were higher than in healthy controls. Case-control differences were larger when considering individuals with chronic and/or severe anxiety disorders, and differences in body composition were modulated by depression comorbidity status. Differences in age-related physiological changes between female anxiety disorder cases and healthy controls were most evident for blood pressure, pulse rate and body composition, while in males for hand-grip strength, blood pressure and body composition. Most differences in physiological measures between cases and controls decreased with increasing age. CONCLUSIONS: Individuals with a lifetime history of anxiety disorders differed from healthy controls across multiple physiological measures, with some evidence of case-control differences by age. The differences observed varied by chronicity/severity and depression comorbidity.
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Personal name Hoppen, Thole H.
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Personal name Fabbri, Chiara
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Personal name Lewis, Cathryn M.
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9 (RLIN) 1321
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Note Br J Psychiatry
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Uniform Resource Identifier <a href="http://dx.doi.org/10.1192/bjp.2021.189">http://dx.doi.org/10.1192/bjp.2021.189</a>
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