Tanycytes Control Hypothalamic Liraglutide Uptake and its Anti-Obesity Actions (Record no. 1693)
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042 ## - AUTHENTICATION CODE | |
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Authentication code | dc |
100 10 - MAIN ENTRY--PERSONAL NAME | |
Personal name | Imbernon, Monica |
Relator term | author |
245 00 - TITLE STATEMENT | |
Title | Tanycytes Control Hypothalamic Liraglutide Uptake and its Anti-Obesity Actions |
260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
Date of publication, distribution, etc. | 2022-07-05. |
500 ## - GENERAL NOTE | |
General note | /pmc/articles/PMC7613793/ |
500 ## - GENERAL NOTE | |
General note | /pubmed/35716660 |
520 ## - SUMMARY, ETC. | |
Summary, etc. | Liraglutide, an anti-diabetic drug and agonist of the glucagon-like peptide 1 receptor (GLP1R), has recently been approved to treat obesity in individuals with or without type-2 diabetes. Despite its extensive metabolic benefits, the mechanism and site of action of liraglutide remain unclear. Here, we demonstrate that liraglutide is shuttled to target cells in the mouse hypothalamus by specialized ependymoglial cells called tanycytes, bypassing the blood-brain barrier. Selectively silencing GLP1R in tanycytes or inhibiting tanycytic transcytosis by botulinum neurotoxin expression not only hampers liraglutide transport into the brain and its activation of target hypothalamic neurons, but also blocks its anti-obesity effects on food intake, body weight and fat mass, and fatty acid oxidation. Collectively, these striking data indicate that the liraglutide-induced activation of hypothalamic neurons and its downstream metabolic effects are mediated by its tanycytic transport into the mediobasal hypothalamus, strengthening the notion of tanycytes as key regulators of metabolic homeostasis. |
540 ## - TERMS GOVERNING USE AND REPRODUCTION NOTE | |
Terms governing use and reproduction | |
546 ## - LANGUAGE NOTE | |
Language note | en |
690 ## - LOCAL SUBJECT ADDED ENTRY--TOPICAL TERM (OCLC, RLIN) | |
Topical term or geographic name as entry element | Article |
655 7# - INDEX TERM--GENRE/FORM | |
Genre/form data or focus term | Text |
Source of term | local |
700 10 - ADDED ENTRY--PERSONAL NAME | |
Personal name | Saponaro, Chiara |
Relator term | author |
9 (RLIN) | 1462 |
700 10 - ADDED ENTRY--PERSONAL NAME | |
Personal name | Helms, Hans Christian Cederberg |
Relator term | author |
9 (RLIN) | 1463 |
700 10 - ADDED ENTRY--PERSONAL NAME | |
Personal name | Duquenne, Manon |
Relator term | author |
9 (RLIN) | 1464 |
700 10 - ADDED ENTRY--PERSONAL NAME | |
Personal name | Fernandois, Daniela |
Relator term | author |
9 (RLIN) | 1465 |
700 10 - ADDED ENTRY--PERSONAL NAME | |
Personal name | Deligia, Eleonora |
Relator term | author |
9 (RLIN) | 1466 |
700 10 - ADDED ENTRY--PERSONAL NAME | |
Personal name | Denis, Raphael G.P. |
Relator term | author |
9 (RLIN) | 1467 |
700 10 - ADDED ENTRY--PERSONAL NAME | |
Personal name | Chao, Daniela Herrera Moro |
Relator term | author |
9 (RLIN) | 1468 |
700 10 - ADDED ENTRY--PERSONAL NAME | |
Personal name | Rasika, S. |
Relator term | author |
700 10 - ADDED ENTRY--PERSONAL NAME | |
Personal name | Staels, Bart |
Relator term | author |
9 (RLIN) | 1470 |
700 10 - ADDED ENTRY--PERSONAL NAME | |
Personal name | Pattou, François |
Relator term | author |
9 (RLIN) | 1471 |
700 10 - ADDED ENTRY--PERSONAL NAME | |
Personal name | Pfrieger, Frank W. |
Relator term | author |
9 (RLIN) | 1472 |
700 10 - ADDED ENTRY--PERSONAL NAME | |
Personal name | Brodin, Birger |
Relator term | author |
9 (RLIN) | 1473 |
700 10 - ADDED ENTRY--PERSONAL NAME | |
Personal name | Luquet, Serge |
Relator term | author |
9 (RLIN) | 1474 |
700 10 - ADDED ENTRY--PERSONAL NAME | |
Personal name | Bonner, Caroline |
Relator term | author |
9 (RLIN) | 1475 |
700 10 - ADDED ENTRY--PERSONAL NAME | |
Personal name | Prevot, Vincent |
Relator term | author |
786 0# - DATA SOURCE ENTRY | |
Note | Cell Metab |
856 41 - ELECTRONIC LOCATION AND ACCESS | |
Uniform Resource Identifier | <a href="http://dx.doi.org/10.1016/j.cmet.2022.06.002">http://dx.doi.org/10.1016/j.cmet.2022.06.002</a> |
Public note | Connect to this object online. |
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