JOM KITA KE POLITEKNIK

Glial cells as integrators of peripheral and central signals in the regulation of energy homeostasis (Record no. 1696)

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Personal name Nampoothiri, Sreekala
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9 (RLIN) 1477
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Title Glial cells as integrators of peripheral and central signals in the regulation of energy homeostasis
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Date of publication, distribution, etc. 2022-07-01.
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General note /pmc/articles/PMC7613794/
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General note /pubmed/35879459
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Summary, etc. Communication between the periphery and the brain is key for maintaining energy homeostasis. To do so, peripheral signals from the circulation reach the brain via the circumventricular organs (CVOs), which are characterized by fenestrated vessels lacking the protective blood-brain barrier (BBB). Glial cells, by virtue of their plasticity and their ideal location at the interface of blood vessels and neurons, participate in the integration and transmission of peripheral information to neuronal networks within the brain for the neuroendocrine control of whole-body metabolism. Metabolic diseases, such as obesity and type 2 diabetes, can disrupt the brain-to-periphery communication mediated by glial cells, highlighting the relevance of these cell types in the pathophysiology of such complications. An improved understanding of how glial cells integrate and respond to metabolic and humoral signals has become a priority for the discovery of promising therapeutic strategies to treat metabolic disorders. This review highlights the role of glial cells in the exchange of metabolic signals between the periphery and the brain that are relevant for the regulation of whole-body energy homeostasis.
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Language note en
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Personal name Nogueiras, Ruben
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9 (RLIN) 1478
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Personal name Schwaninger, Markus
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9 (RLIN) 1479
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Personal name Prevot, Vincent
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Note Nat Metab
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Uniform Resource Identifier <a href="http://dx.doi.org/10.1038/s42255-022-00610-z">http://dx.doi.org/10.1038/s42255-022-00610-z</a>
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