JOM KITA KE POLITEKNIK

Staggered starts in the race to T cell activation (Record no. 1706)

MARC details
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Personal name Richard, Arianne C.
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9 (RLIN) 1043
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Title Staggered starts in the race to T cell activation
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Date of publication, distribution, etc. 2021-11-01.
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General note /pmc/articles/PMC7612485/
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General note /pubmed/34649777
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Summary, etc. How T lymphocytes tune their responses to different strengths of stimulation is a fundamental question in immunology. Recent work using new optogenetic, single-cell genomic and live-imaging approaches has revealed that stimulation strength controls the rate of individual cell responses within a population. Moreover, these responses have been found to use shared molecular programs, regardless of stimulation strength. However, additional data indicate that stimulation duration or cytokine feedback can impact later gene expression phenotypes of activated cells. In-depth molecular studies have suggested mechanisms by which stimulation strength might modulate the probability of T cell activation. This emerging model allows activating T cells to achieve a wide range of population responses through probabilistic control within individual cells.
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Terms governing use and reproduction
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Terms governing use and reproduction https://creativecommons.org/licenses/by/4.0/This work is licensed under a CC BY 4.0 (https://creativecommons.org/licenses/by/4.0/) International license.
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Language note en
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Topical term or geographic name as entry element Article
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Genre/form data or focus term Text
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Personal name Frazer, Gordon L.
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9 (RLIN) 1044
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Personal name Ma, Claire Y.
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Personal name Griffiths, Gillian M
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Note Trends Immunol
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Uniform Resource Identifier <a href="http://dx.doi.org/10.1016/j.it.2021.09.004">http://dx.doi.org/10.1016/j.it.2021.09.004</a>
Public note Connect to this object online.

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