Breastfeeding may benefit cardiometabolic health of children exposed to increased gestational glycemia in utero (Record no. 1731)
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042 ## - AUTHENTICATION CODE | |
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Authentication code | dc |
100 10 - MAIN ENTRY--PERSONAL NAME | |
Personal name | Ong, Yi Ying |
Relator term | author |
9 (RLIN) | 1128 |
245 00 - TITLE STATEMENT | |
Title | Breastfeeding may benefit cardiometabolic health of children exposed to increased gestational glycemia in utero |
260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
Date of publication, distribution, etc. | 2022-08. |
500 ## - GENERAL NOTE | |
General note | /pmc/articles/PMC7613060/ |
500 ## - GENERAL NOTE | |
General note | /pubmed/35124728 |
520 ## - SUMMARY, ETC. | |
Summary, etc. | PURPOSE: There is altered breastmilk composition among mothers with gestational diabetes and conflicting evidence on whether breastfeeding is beneficial or detrimental to their offspring's cardiometabolic health. We aimed to investigate associations between breastfeeding and offspring's cardiometabolic health across the range of gestational glycemia. METHODS: We included 827 naturally-conceived, term singletons from a prospective mother-child cohort. We measured gestational (26-28weeks) fasting plasma glucose (FPG) and 2-hour plasma glucose (2hrPG) after an oral glucose tolerance test as continuous variables. Participants were classified into 2 breastfeeding categories (high/intermediate vs. low) according to their breastfeeding duration and exclusivity. Main outcome measures included magnetic resonance imaging (MRI)-measured abdominal fat, intramyocellular lipids (IMCL), and liver fat, quantitative magnetic resonance (QMR)-measured body fat mass, blood pressure, blood lipids, and insulin resistance at 6 years old (all continuous variables). We evaluated if gestational glycemia (FPG & 2hrPG) modified the association of breastfeeding with offspring outcomes after adjusting for confounders using a multiple linear regression model that included a 'gestational glycemia x breastfeeding' interaction term. RESULTS: With increasing gestational FPG, high/intermediate (vs. low) breastfeeding was associated with lower levels of IMCL (p-interaction=0.047), liver fat (p-interaction=0.033), and triglycerides (p-interaction=0.007), after adjusting for confounders. Specifically, at 2 standard deviations above the mean gestational FPG level, high/intermediate (vs. low) breastfeeding was linked to lower adjusted mean IMCL (0.39% of water signal [0.29,0.50] vs. 0.54% of water signal [0.46,0.62]), liver fat (0.39% by weight [0.20,0.58] vs. 0.72% by weight [0.59,0.85]), and triglycerides (0.62mmol/L [0.51,0.72] vs. 0.86mmol/L [0.75,0.97]). 2hrPG did not significantly modify the association between breastfeeding and childhood cardiometabolic risk. CONCLUSION: Our findings suggest breastfeeding may confer protection against adverse fat partitioning and higher triglyceride concentration among children exposed to increased glycemia in utero. |
540 ## - TERMS GOVERNING USE AND REPRODUCTION NOTE | |
Terms governing use and reproduction | |
546 ## - LANGUAGE NOTE | |
Language note | en |
690 ## - LOCAL SUBJECT ADDED ENTRY--TOPICAL TERM (OCLC, RLIN) | |
Topical term or geographic name as entry element | Article |
655 7# - INDEX TERM--GENRE/FORM | |
Genre/form data or focus term | Text |
Source of term | local |
700 10 - ADDED ENTRY--PERSONAL NAME | |
Personal name | Pang, Wei Wei |
Relator term | author |
9 (RLIN) | 1129 |
700 10 - ADDED ENTRY--PERSONAL NAME | |
Personal name | Huang, Jonathan Y. |
Relator term | author |
9 (RLIN) | 1130 |
700 10 - ADDED ENTRY--PERSONAL NAME | |
Personal name | Aris, Izzuddin M. |
Relator term | author |
9 (RLIN) | 1131 |
700 10 - ADDED ENTRY--PERSONAL NAME | |
Personal name | Sadananthan, Suresh Anand |
Relator term | author |
9 (RLIN) | 1132 |
700 10 - ADDED ENTRY--PERSONAL NAME | |
Personal name | Tint, Mya-Thway |
Relator term | author |
9 (RLIN) | 1133 |
700 10 - ADDED ENTRY--PERSONAL NAME | |
Personal name | Yuan, Wen Lun |
Relator term | author |
9 (RLIN) | 1134 |
700 10 - ADDED ENTRY--PERSONAL NAME | |
Personal name | Chen, Ling-Wei |
Relator term | author |
9 (RLIN) | 1135 |
700 10 - ADDED ENTRY--PERSONAL NAME | |
Personal name | Chan, Yiong Huak |
Relator term | author |
9 (RLIN) | 1136 |
700 10 - ADDED ENTRY--PERSONAL NAME | |
Personal name | Karnani, Neerja |
Relator term | author |
9 (RLIN) | 1137 |
700 10 - ADDED ENTRY--PERSONAL NAME | |
Personal name | Velan, S. Sendhil |
Relator term | author |
9 (RLIN) | 1138 |
700 10 - ADDED ENTRY--PERSONAL NAME | |
Personal name | Fortier, Marielle V. |
Relator term | author |
9 (RLIN) | 1139 |
700 10 - ADDED ENTRY--PERSONAL NAME | |
Personal name | Choo, Jonathan |
Relator term | author |
9 (RLIN) | 1140 |
700 10 - ADDED ENTRY--PERSONAL NAME | |
Personal name | Ling, Lieng Hsi |
Relator term | author |
9 (RLIN) | 1141 |
700 10 - ADDED ENTRY--PERSONAL NAME | |
Personal name | Shek, Lynette |
Relator term | author |
9 (RLIN) | 1142 |
700 10 - ADDED ENTRY--PERSONAL NAME | |
Personal name | Tan, Kok Hian |
Relator term | author |
9 (RLIN) | 1143 |
700 10 - ADDED ENTRY--PERSONAL NAME | |
Personal name | Gluckman, Peter D. |
Relator term | author |
9 (RLIN) | 1144 |
700 10 - ADDED ENTRY--PERSONAL NAME | |
Personal name | Yap, Fabian |
Relator term | author |
9 (RLIN) | 1145 |
700 10 - ADDED ENTRY--PERSONAL NAME | |
Personal name | Chong, Yap-Seng |
Relator term | author |
9 (RLIN) | 1146 |
700 10 - ADDED ENTRY--PERSONAL NAME | |
Personal name | Godfrey, Keith M. |
Relator term | author |
9 (RLIN) | 1147 |
700 10 - ADDED ENTRY--PERSONAL NAME | |
Personal name | Chong, Mary F-F. |
Relator term | author |
9 (RLIN) | 1148 |
700 10 - ADDED ENTRY--PERSONAL NAME | |
Personal name | Chan, Shiao-Yng |
Relator term | author |
9 (RLIN) | 1149 |
700 10 - ADDED ENTRY--PERSONAL NAME | |
Personal name | Eriksson, Johan G. |
Relator term | author |
9 (RLIN) | 1150 |
700 10 - ADDED ENTRY--PERSONAL NAME | |
Personal name | Wlodek, Mary E. |
Relator term | author |
9 (RLIN) | 1151 |
700 10 - ADDED ENTRY--PERSONAL NAME | |
Personal name | Lee, Yung Seng |
Relator term | author |
9 (RLIN) | 1152 |
700 10 - ADDED ENTRY--PERSONAL NAME | |
Personal name | Michael, Navin |
Relator term | author |
9 (RLIN) | 1153 |
786 0# - DATA SOURCE ENTRY | |
Note | Eur J Nutr |
856 41 - ELECTRONIC LOCATION AND ACCESS | |
Uniform Resource Identifier | <a href="http://dx.doi.org/10.1007/s00394-022-02800-7">http://dx.doi.org/10.1007/s00394-022-02800-7</a> |
Public note | Connect to this object online. |
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