JOM KITA KE POLITEKNIK

Relationship between nuclei-specific amygdala connectivity and mental health dimensions in humans (Record no. 1760)

MARC details
042 ## - AUTHENTICATION CODE
Authentication code dc
100 10 - MAIN ENTRY--PERSONAL NAME
Personal name Klein-Flügge, Miriam C
Relator term author
9 (RLIN) 1757
245 00 - TITLE STATEMENT
Title Relationship between nuclei-specific amygdala connectivity and mental health dimensions in humans
260 ## - PUBLICATION, DISTRIBUTION, ETC.
Date of publication, distribution, etc. 2022-12.
500 ## - GENERAL NOTE
General note /pmc/articles/PMC7613949/
500 ## - GENERAL NOTE
General note /pubmed/36138220
520 ## - SUMMARY, ETC.
Summary, etc. There has been increasing interest in using neuroimaging measures to predict psychiatric disorders. However, predictions usually rely on large brain networks and large disorder heterogeneity. Thus, they lack both anatomical and behavioural specificity, preventing the advancement of targeted interventions. Here, we address both challenges. First, using resting-state functional MRI, we parcellated the amygdala, a region implicated in mood disorders, into seven nuclei. Next, a questionnaire factor analysis provided subclinical mental health dimensions frequently altered in anxious-depressive individuals, such as negative emotions and sleep problems. Finally, for each behavioural dimension, we identified the most predictive resting-state functional connectivity between individual amygdala nuclei and highly specific regions of interest such as the dorsal raphe nucleus in the brainstem or medial frontal cortical regions. Connectivity in circumscribed amygdala networks predicted behaviours in an independent dataset. Our results reveal specific relations between mental health dimensions and connectivity in precise subcortical networks.
540 ## - TERMS GOVERNING USE AND REPRODUCTION NOTE
Terms governing use and reproduction
540 ## - TERMS GOVERNING USE AND REPRODUCTION NOTE
Terms governing use and reproduction https://www.springernature.com/gp/open-research/policies/accepted-manuscript-termsUsers may view, print, copy, and download text and data-mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use: https://www.springernature.com/gp/open-research/policies/accepted-manuscript-terms
546 ## - LANGUAGE NOTE
Language note en
690 ## - LOCAL SUBJECT ADDED ENTRY--TOPICAL TERM (OCLC, RLIN)
Topical term or geographic name as entry element Article
655 7# - INDEX TERM--GENRE/FORM
Genre/form data or focus term Text
Source of term local
700 10 - ADDED ENTRY--PERSONAL NAME
Personal name Jensen, Daria EA
Relator term author
9 (RLIN) 1758
700 10 - ADDED ENTRY--PERSONAL NAME
Personal name Takagi, Yu
Relator term author
9 (RLIN) 1759
700 10 - ADDED ENTRY--PERSONAL NAME
Personal name Priestley, Luke
Relator term author
9 (RLIN) 1760
700 10 - ADDED ENTRY--PERSONAL NAME
Personal name Verhagen, Lennart
Relator term author
9 (RLIN) 1761
700 10 - ADDED ENTRY--PERSONAL NAME
Personal name Smith, Stephen M
Relator term author
9 (RLIN) 1762
700 10 - ADDED ENTRY--PERSONAL NAME
Personal name Rushworth, Matthew FS
Relator term author
9 (RLIN) 1763
786 0# - DATA SOURCE ENTRY
Note Nat Hum Behav
856 41 - ELECTRONIC LOCATION AND ACCESS
Uniform Resource Identifier <a href="http://dx.doi.org/10.1038/s41562-022-01434-3">http://dx.doi.org/10.1038/s41562-022-01434-3</a>
Public note Connect to this object online.

No items available.