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An αvβ3 integrin checkpoint is critical for efficient T(H)2 cytokine polarisation and potentiating antigen-specific immunity (Record no. 1812)

MARC details
042 ## - AUTHENTICATION CODE
Authentication code dc
100 10 - MAIN ENTRY--PERSONAL NAME
Personal name Szeto, Aydan C. H.
Relator term author
9 (RLIN) 1958
245 00 - TITLE STATEMENT
Title An αvβ3 integrin checkpoint is critical for efficient T(H)2 cytokine polarisation and potentiating antigen-specific immunity
260 ## - PUBLICATION, DISTRIBUTION, ETC.
Date of publication, distribution, etc. 2023-01.
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General note /pmc/articles/PMC7614022/
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General note /pubmed/36550322
520 ## - SUMMARY, ETC.
Summary, etc. Naïve CD4(+) T lymphocytes initially undergo antigen-specific activation to promote a broad-spectrum response before adopting bespoke cytokine expression profiles shaped by intercellular microenvironmental cues, resulting in pathogen-focussed modular cytokine responses. Interleukin (IL)-4-induced Gata3 upregulation is important for the T helper 2 (T(H)2) cell polarisation associated with anti-helminth immunity and misdirected allergic inflammation. Whether additional microenvironmental factors participate is unclear. Using whole mouse-genome CRISPR-Cas9 screens we discovered a previously unappreciated role for αvβ3 integrin in T(H)2 cell differentiation. Low-level αvβ3 expression by naïve CD4(+) T cells contributed to pan-T cell activation by promoting T-T cell clustering and IL-2/CD25/STAT5-signalling. Subsequently, IL-4/Gata3-induced selective upregulation of αvβ3 licenced intercellular αvβ3-Thy1 interactions among T(H)2 cells, enhanced mTOR signalling, supported differentiation and promoted IL-5/IL-13 production. In mice, αvβ3 was required for efficient allergen-driven antigen-specific lung T(H)2 cell responses. Thus, αvβ3-expressing T(H)2 cells form multicellular factories to propagate and amplify T(H)2 responses.
540 ## - TERMS GOVERNING USE AND REPRODUCTION NOTE
Terms governing use and reproduction
540 ## - TERMS GOVERNING USE AND REPRODUCTION NOTE
Terms governing use and reproduction https://creativecommons.org/licenses/by/4.0/This work is licensed under a CC BY 4.0 (https://creativecommons.org/licenses/by/4.0/) International license.
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Language note en
690 ## - LOCAL SUBJECT ADDED ENTRY--TOPICAL TERM (OCLC, RLIN)
Topical term or geographic name as entry element Article
655 7# - INDEX TERM--GENRE/FORM
Genre/form data or focus term Text
Source of term local
700 10 - ADDED ENTRY--PERSONAL NAME
Personal name Ferreira, Ana C. F.
Relator term author
9 (RLIN) 1959
700 10 - ADDED ENTRY--PERSONAL NAME
Personal name Mannion, Jonathan
Relator term author
9 (RLIN) 1960
700 10 - ADDED ENTRY--PERSONAL NAME
Personal name Clark, Paula A.
Relator term author
9 (RLIN) 1961
700 10 - ADDED ENTRY--PERSONAL NAME
Personal name Sivasubramaniam, Meera
Relator term author
9 (RLIN) 1962
700 10 - ADDED ENTRY--PERSONAL NAME
Personal name Heycock, Morgan W. D.
Relator term author
9 (RLIN) 1963
700 10 - ADDED ENTRY--PERSONAL NAME
Personal name Crisp, Alastair
Relator term author
9 (RLIN) 1964
700 10 - ADDED ENTRY--PERSONAL NAME
Personal name Jolin, Helen E.
Relator term author
9 (RLIN) 1965
700 10 - ADDED ENTRY--PERSONAL NAME
Personal name Kozik, Patrycja
Relator term author
9 (RLIN) 1966
700 10 - ADDED ENTRY--PERSONAL NAME
Personal name Knolle, Martin D.
Relator term author
9 (RLIN) 1967
700 10 - ADDED ENTRY--PERSONAL NAME
Personal name McKenzie, Andrew N. J.
Relator term author
9 (RLIN) 1968
786 0# - DATA SOURCE ENTRY
Note Nat Immunol
856 41 - ELECTRONIC LOCATION AND ACCESS
Uniform Resource Identifier <a href="http://dx.doi.org/10.1038/s41590-022-01378-w">http://dx.doi.org/10.1038/s41590-022-01378-w</a>
Public note Connect to this object online.

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