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Intracellular chloride regulation mediates local sleep pressure in the cortex (Record no. 1841)

MARC details
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Personal name Alfonsa, Hannah
Relator term author
9 (RLIN) 2084
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Title Intracellular chloride regulation mediates local sleep pressure in the cortex
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Date of publication, distribution, etc. 2023-01.
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General note /pmc/articles/PMC7614036/
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General note /pubmed/36510112
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Summary, etc. Extended wakefulness is associated with reduced performance and the build-up of sleep pressure. In the cortex, this manifests as changes in network activity. These changes show local variation depending on the waking experience, and their underlying mechanisms represent targets for overcoming the effects of tiredness. Here we reveal a central role for intracellular chloride regulation, which sets the strength of postsynaptic inhibition via GABA(A) receptors in cortical pyramidal neurons. Wakefulness results in depolarizing shifts in the equilibrium potential for GABA(A) receptors, reflecting local activity-dependent processes during waking, and involving changes in chloride cotransporter activity. These changes underlie electrophysiological and behavioral markers of local sleep pressure within cortex - including the levels of slow-wave activity during non-rapid eye movement sleep - as well as low-frequency oscillatory activity and reduced performance levels in the sleep-deprived awake state. These findings identify chloride regulation as a crucial link between sleep-wake history, cortical activity and behavior.
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Terms governing use and reproduction
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Terms governing use and reproduction https://www.springernature.com/gp/open-research/policies/accepted-manuscript-termsUsers may view, print, copy, and download text and data-mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use: https://www.springernature.com/gp/open-research/policies/accepted-manuscript-terms
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Language note en
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Topical term or geographic name as entry element Article
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Genre/form data or focus term Text
Source of term local
700 10 - ADDED ENTRY--PERSONAL NAME
Personal name Burman, Richard J.
Relator term author
9 (RLIN) 2085
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Personal name Brodersen, Paul J. N.
Relator term author
9 (RLIN) 2086
700 10 - ADDED ENTRY--PERSONAL NAME
Personal name Newey, Sarah E.
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9 (RLIN) 2087
700 10 - ADDED ENTRY--PERSONAL NAME
Personal name Mahfooz, Kashif
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9 (RLIN) 2088
700 10 - ADDED ENTRY--PERSONAL NAME
Personal name Yamagata, Tomoko
Relator term author
9 (RLIN) 2089
700 10 - ADDED ENTRY--PERSONAL NAME
Personal name Panayi, Marios C.
Relator term author
9 (RLIN) 2090
700 10 - ADDED ENTRY--PERSONAL NAME
Personal name Bannerman, David M.
Relator term author
9 (RLIN) 2091
700 10 - ADDED ENTRY--PERSONAL NAME
Personal name Vyazovskiy, Vladyslav V.
Relator term author
9 (RLIN) 2092
700 10 - ADDED ENTRY--PERSONAL NAME
Personal name Akerman, Colin J.
Relator term author
9 (RLIN) 2093
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Note Nat Neurosci
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Uniform Resource Identifier <a href="http://dx.doi.org/10.1038/s41593-022-01214-2">http://dx.doi.org/10.1038/s41593-022-01214-2</a>
Public note Connect to this object online.

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