JOM KITA KE POLITEKNIK

Breastfeeding may benefit cardiometabolic health of children exposed to increased gestational glycemia in utero (Record no. 1845)

MARC details
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100 10 - MAIN ENTRY--PERSONAL NAME
Personal name Ong, Yi Ying
Relator term author
9 (RLIN) 1128
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Title Breastfeeding may benefit cardiometabolic health of children exposed to increased gestational glycemia in utero
260 ## - PUBLICATION, DISTRIBUTION, ETC.
Date of publication, distribution, etc. 2022-08.
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General note /pmc/articles/PMC7613060/
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General note /pubmed/35124728
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Summary, etc. PURPOSE: There is altered breastmilk composition among mothers with gestational diabetes and conflicting evidence on whether breastfeeding is beneficial or detrimental to their offspring's cardiometabolic health. We aimed to investigate associations between breastfeeding and offspring's cardiometabolic health across the range of gestational glycemia. METHODS: We included 827 naturally-conceived, term singletons from a prospective mother-child cohort. We measured gestational (26-28weeks) fasting plasma glucose (FPG) and 2-hour plasma glucose (2hrPG) after an oral glucose tolerance test as continuous variables. Participants were classified into 2 breastfeeding categories (high/intermediate vs. low) according to their breastfeeding duration and exclusivity. Main outcome measures included magnetic resonance imaging (MRI)-measured abdominal fat, intramyocellular lipids (IMCL), and liver fat, quantitative magnetic resonance (QMR)-measured body fat mass, blood pressure, blood lipids, and insulin resistance at 6 years old (all continuous variables). We evaluated if gestational glycemia (FPG & 2hrPG) modified the association of breastfeeding with offspring outcomes after adjusting for confounders using a multiple linear regression model that included a 'gestational glycemia x breastfeeding' interaction term. RESULTS: With increasing gestational FPG, high/intermediate (vs. low) breastfeeding was associated with lower levels of IMCL (p-interaction=0.047), liver fat (p-interaction=0.033), and triglycerides (p-interaction=0.007), after adjusting for confounders. Specifically, at 2 standard deviations above the mean gestational FPG level, high/intermediate (vs. low) breastfeeding was linked to lower adjusted mean IMCL (0.39% of water signal [0.29,0.50] vs. 0.54% of water signal [0.46,0.62]), liver fat (0.39% by weight [0.20,0.58] vs. 0.72% by weight [0.59,0.85]), and triglycerides (0.62mmol/L [0.51,0.72] vs. 0.86mmol/L [0.75,0.97]). 2hrPG did not significantly modify the association between breastfeeding and childhood cardiometabolic risk. CONCLUSION: Our findings suggest breastfeeding may confer protection against adverse fat partitioning and higher triglyceride concentration among children exposed to increased glycemia in utero.
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Language note en
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Topical term or geographic name as entry element Article
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Personal name Pang, Wei Wei
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9 (RLIN) 1129
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Personal name Huang, Jonathan Y.
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9 (RLIN) 1130
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Personal name Aris, Izzuddin M.
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9 (RLIN) 1131
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Personal name Sadananthan, Suresh Anand
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9 (RLIN) 1132
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Personal name Tint, Mya-Thway
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9 (RLIN) 1133
700 10 - ADDED ENTRY--PERSONAL NAME
Personal name Yuan, Wen Lun
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9 (RLIN) 1134
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Personal name Chen, Ling-Wei
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9 (RLIN) 1135
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Personal name Chan, Yiong Huak
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9 (RLIN) 1136
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Personal name Karnani, Neerja
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9 (RLIN) 1137
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Personal name Velan, S. Sendhil
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9 (RLIN) 1138
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Personal name Fortier, Marielle V.
Relator term author
9 (RLIN) 1139
700 10 - ADDED ENTRY--PERSONAL NAME
Personal name Choo, Jonathan
Relator term author
9 (RLIN) 1140
700 10 - ADDED ENTRY--PERSONAL NAME
Personal name Ling, Lieng Hsi
Relator term author
9 (RLIN) 1141
700 10 - ADDED ENTRY--PERSONAL NAME
Personal name Shek, Lynette
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9 (RLIN) 1142
700 10 - ADDED ENTRY--PERSONAL NAME
Personal name Tan, Kok Hian
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9 (RLIN) 1143
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Personal name Gluckman, Peter D.
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9 (RLIN) 1144
700 10 - ADDED ENTRY--PERSONAL NAME
Personal name Yap, Fabian
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9 (RLIN) 1145
700 10 - ADDED ENTRY--PERSONAL NAME
Personal name Chong, Yap-Seng
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9 (RLIN) 1146
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Personal name Godfrey, Keith M.
Relator term author
9 (RLIN) 1147
700 10 - ADDED ENTRY--PERSONAL NAME
Personal name Chong, Mary F-F.
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9 (RLIN) 1148
700 10 - ADDED ENTRY--PERSONAL NAME
Personal name Chan, Shiao-Yng
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9 (RLIN) 1149
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Personal name Eriksson, Johan G.
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9 (RLIN) 1150
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Personal name Wlodek, Mary E.
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9 (RLIN) 1151
700 10 - ADDED ENTRY--PERSONAL NAME
Personal name Lee, Yung Seng
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9 (RLIN) 1152
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Personal name Michael, Navin
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9 (RLIN) 1153
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Note Eur J Nutr
856 41 - ELECTRONIC LOCATION AND ACCESS
Uniform Resource Identifier <a href="http://dx.doi.org/10.1007/s00394-022-02800-7">http://dx.doi.org/10.1007/s00394-022-02800-7</a>
Public note Connect to this object online.

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