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An improved imaging system that corrects MS2-induced RNA destabilization (Record no. 1868)

MARC details
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Authentication code dc
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Personal name Li, Weihan
Relator term author
9 (RLIN) 1716
245 00 - TITLE STATEMENT
Title An improved imaging system that corrects MS2-induced RNA destabilization
260 ## - PUBLICATION, DISTRIBUTION, ETC.
Date of publication, distribution, etc. 2022-12.
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General note /pmc/articles/PMC7613886/
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General note /pubmed/36357695
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Summary, etc. The MS2-MCP imaging system is widely used to study mRNA spatial distribution in living cells. Here, we report that the MS2-MCP system destabilizes some tagged mRNAs by targeting them to the nonsense-mediated mRNA decay pathway. We introduce an improved version, which counteracts this effect by increasing the efficiency of translation termination of the tagged mRNAs. Improved versions were developed for both yeast and mammalian systems.
540 ## - TERMS GOVERNING USE AND REPRODUCTION NOTE
Terms governing use and reproduction
540 ## - TERMS GOVERNING USE AND REPRODUCTION NOTE
Terms governing use and reproduction https://www.springernature.com/gp/open-research/policies/accepted-manuscript-termsUsers may view, print, copy, and download text and data-mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use: https://www.springernature.com/gp/open-research/policies/accepted-manuscript-terms
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Language note en
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Topical term or geographic name as entry element Article
655 7# - INDEX TERM--GENRE/FORM
Genre/form data or focus term Text
Source of term local
700 10 - ADDED ENTRY--PERSONAL NAME
Personal name Maekiniemi, Anna
Relator term author
9 (RLIN) 1717
700 10 - ADDED ENTRY--PERSONAL NAME
Personal name Sato, Hanae
Relator term author
9 (RLIN) 1718
700 10 - ADDED ENTRY--PERSONAL NAME
Personal name Osman, Christof
Relator term author
9 (RLIN) 1719
700 10 - ADDED ENTRY--PERSONAL NAME
Personal name Singer, Robert H.
Relator term author
9 (RLIN) 1720
786 0# - DATA SOURCE ENTRY
Note Nat Methods
856 41 - ELECTRONIC LOCATION AND ACCESS
Uniform Resource Identifier <a href="http://dx.doi.org/10.1038/s41592-022-01658-1">http://dx.doi.org/10.1038/s41592-022-01658-1</a>
Public note Connect to this object online.

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