JOM KITA KE POLITEKNIK

Mechanical stress driven by rigidity sensing governs epithelial stability (Record no. 1928)

MARC details
042 ## - AUTHENTICATION CODE
Authentication code dc
100 10 - MAIN ENTRY--PERSONAL NAME
Personal name Sonam, Surabhi
Relator term author
9 (RLIN) 2319
245 00 - TITLE STATEMENT
Title Mechanical stress driven by rigidity sensing governs epithelial stability
260 ## - PUBLICATION, DISTRIBUTION, ETC.
Date of publication, distribution, etc. 2023-01.
500 ## - GENERAL NOTE
General note /pmc/articles/PMC7614076/
500 ## - GENERAL NOTE
General note /pubmed/36686215
520 ## - SUMMARY, ETC.
Summary, etc. Epithelia act as a barrier against environmental stress and abrasion and in vivo they are continuously exposed to environments of various mechanical properties. The impact of this environment on epithelial integrity remains elusive. By culturing epithelial cells on 2D hydrogels, we observe a loss of epithelial monolayer integrity through spontaneous hole formation when grown on soft substrates. Substrate stiffness triggers an unanticipated mechanical switch of epithelial monolayers from tensile on soft to compressive on stiff substrates. Through active nematic modelling, we find that spontaneous half-integer defect formation underpinning large isotropic stress fluctuations initiate hole opening events. Our data show that monolayer rupture due to high tensile stress is promoted by the weakening of cell-cell junctions that could be induced by cell division events or local cellular stretching. Our results show that substrate stiffness provides feedback on monolayer mechanical state and that topological defects can trigger stochastic mechanical failure, with potential application towards a mechanistic understanding of compromised epithelial integrity during immune response and morphogenesis.
540 ## - TERMS GOVERNING USE AND REPRODUCTION NOTE
Terms governing use and reproduction
540 ## - TERMS GOVERNING USE AND REPRODUCTION NOTE
Terms governing use and reproduction https://www.springernature.com/gp/open-research/policies/accepted-manuscript-termsUsers may view, print, copy, and download text and data-mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use: https://www.springernature.com/gp/open-research/policies/accepted-manuscript-terms
546 ## - LANGUAGE NOTE
Language note en
690 ## - LOCAL SUBJECT ADDED ENTRY--TOPICAL TERM (OCLC, RLIN)
Topical term or geographic name as entry element Article
655 7# - INDEX TERM--GENRE/FORM
Genre/form data or focus term Text
Source of term local
700 10 - ADDED ENTRY--PERSONAL NAME
Personal name Balasubramaniam, Lakshmi
Relator term author
9 (RLIN) 2320
700 10 - ADDED ENTRY--PERSONAL NAME
Personal name Lin, Shao-Zhen
Relator term author
9 (RLIN) 2321
700 10 - ADDED ENTRY--PERSONAL NAME
Personal name Ivan, Ying Ming Yow
Relator term author
9 (RLIN) 2322
700 10 - ADDED ENTRY--PERSONAL NAME
Personal name Jaumà, Irina Pi
Relator term author
9 (RLIN) 2323
700 10 - ADDED ENTRY--PERSONAL NAME
Personal name Jebane, Cecile
Relator term author
9 (RLIN) 2324
700 10 - ADDED ENTRY--PERSONAL NAME
Personal name Karnat, Marc
Relator term author
9 (RLIN) 2325
700 10 - ADDED ENTRY--PERSONAL NAME
Personal name Toyama, Yusuke
Relator term author
9 (RLIN) 2326
700 10 - ADDED ENTRY--PERSONAL NAME
Personal name Marcq, Philippe
Relator term author
9 (RLIN) 2327
700 10 - ADDED ENTRY--PERSONAL NAME
Personal name Prost, Jacques
Relator term author
9 (RLIN) 2328
700 10 - ADDED ENTRY--PERSONAL NAME
Personal name Mège, René-Marc
Relator term author
9 (RLIN) 2329
700 10 - ADDED ENTRY--PERSONAL NAME
Personal name Rupprecht, Jean-François
Relator term author
9 (RLIN) 2330
700 10 - ADDED ENTRY--PERSONAL NAME
Personal name Ladoux, Benoît
Relator term author
9 (RLIN) 2331
786 0# - DATA SOURCE ENTRY
Note Nat Phys
856 41 - ELECTRONIC LOCATION AND ACCESS
Uniform Resource Identifier <a href="http://dx.doi.org/10.1038/s41567-022-01826-2">http://dx.doi.org/10.1038/s41567-022-01826-2</a>
Public note Connect to this object online.

No items available.