Mechanical stress driven by rigidity sensing governs epithelial stability (Record no. 1928)
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042 ## - AUTHENTICATION CODE | |
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Authentication code | dc |
100 10 - MAIN ENTRY--PERSONAL NAME | |
Personal name | Sonam, Surabhi |
Relator term | author |
9 (RLIN) | 2319 |
245 00 - TITLE STATEMENT | |
Title | Mechanical stress driven by rigidity sensing governs epithelial stability |
260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
Date of publication, distribution, etc. | 2023-01. |
500 ## - GENERAL NOTE | |
General note | /pmc/articles/PMC7614076/ |
500 ## - GENERAL NOTE | |
General note | /pubmed/36686215 |
520 ## - SUMMARY, ETC. | |
Summary, etc. | Epithelia act as a barrier against environmental stress and abrasion and in vivo they are continuously exposed to environments of various mechanical properties. The impact of this environment on epithelial integrity remains elusive. By culturing epithelial cells on 2D hydrogels, we observe a loss of epithelial monolayer integrity through spontaneous hole formation when grown on soft substrates. Substrate stiffness triggers an unanticipated mechanical switch of epithelial monolayers from tensile on soft to compressive on stiff substrates. Through active nematic modelling, we find that spontaneous half-integer defect formation underpinning large isotropic stress fluctuations initiate hole opening events. Our data show that monolayer rupture due to high tensile stress is promoted by the weakening of cell-cell junctions that could be induced by cell division events or local cellular stretching. Our results show that substrate stiffness provides feedback on monolayer mechanical state and that topological defects can trigger stochastic mechanical failure, with potential application towards a mechanistic understanding of compromised epithelial integrity during immune response and morphogenesis. |
540 ## - TERMS GOVERNING USE AND REPRODUCTION NOTE | |
Terms governing use and reproduction | |
540 ## - TERMS GOVERNING USE AND REPRODUCTION NOTE | |
Terms governing use and reproduction | https://www.springernature.com/gp/open-research/policies/accepted-manuscript-termsUsers may view, print, copy, and download text and data-mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use: https://www.springernature.com/gp/open-research/policies/accepted-manuscript-terms |
546 ## - LANGUAGE NOTE | |
Language note | en |
690 ## - LOCAL SUBJECT ADDED ENTRY--TOPICAL TERM (OCLC, RLIN) | |
Topical term or geographic name as entry element | Article |
655 7# - INDEX TERM--GENRE/FORM | |
Genre/form data or focus term | Text |
Source of term | local |
700 10 - ADDED ENTRY--PERSONAL NAME | |
Personal name | Balasubramaniam, Lakshmi |
Relator term | author |
9 (RLIN) | 2320 |
700 10 - ADDED ENTRY--PERSONAL NAME | |
Personal name | Lin, Shao-Zhen |
Relator term | author |
9 (RLIN) | 2321 |
700 10 - ADDED ENTRY--PERSONAL NAME | |
Personal name | Ivan, Ying Ming Yow |
Relator term | author |
9 (RLIN) | 2322 |
700 10 - ADDED ENTRY--PERSONAL NAME | |
Personal name | Jaumà, Irina Pi |
Relator term | author |
9 (RLIN) | 2323 |
700 10 - ADDED ENTRY--PERSONAL NAME | |
Personal name | Jebane, Cecile |
Relator term | author |
9 (RLIN) | 2324 |
700 10 - ADDED ENTRY--PERSONAL NAME | |
Personal name | Karnat, Marc |
Relator term | author |
9 (RLIN) | 2325 |
700 10 - ADDED ENTRY--PERSONAL NAME | |
Personal name | Toyama, Yusuke |
Relator term | author |
9 (RLIN) | 2326 |
700 10 - ADDED ENTRY--PERSONAL NAME | |
Personal name | Marcq, Philippe |
Relator term | author |
9 (RLIN) | 2327 |
700 10 - ADDED ENTRY--PERSONAL NAME | |
Personal name | Prost, Jacques |
Relator term | author |
9 (RLIN) | 2328 |
700 10 - ADDED ENTRY--PERSONAL NAME | |
Personal name | Mège, René-Marc |
Relator term | author |
9 (RLIN) | 2329 |
700 10 - ADDED ENTRY--PERSONAL NAME | |
Personal name | Rupprecht, Jean-François |
Relator term | author |
9 (RLIN) | 2330 |
700 10 - ADDED ENTRY--PERSONAL NAME | |
Personal name | Ladoux, Benoît |
Relator term | author |
9 (RLIN) | 2331 |
786 0# - DATA SOURCE ENTRY | |
Note | Nat Phys |
856 41 - ELECTRONIC LOCATION AND ACCESS | |
Uniform Resource Identifier | <a href="http://dx.doi.org/10.1038/s41567-022-01826-2">http://dx.doi.org/10.1038/s41567-022-01826-2</a> |
Public note | Connect to this object online. |
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