JOM KITA KE POLITEKNIK

Reciprocal cortico-amygdala connections regulate prosocial and selfish choices in mice (Record no. 1947)

MARC details
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Personal name Scheggia, Diego
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9 (RLIN) 1443
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Title Reciprocal cortico-amygdala connections regulate prosocial and selfish choices in mice
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Date of publication, distribution, etc. 2022-11.
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General note /pmc/articles/PMC7613781/
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General note /pubmed/36280797
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Summary, etc. Decisions that favor one's own interest versus the interest of another individual depend on context and the relationships between individuals. The neurobiology underlying selfish choices or choices that benefit others is not understood. We developed a two-choice social decision-making task in which mice can decide whether or not to share a reward with their conspecifics. Preference for altruistic choices was modulated by familiarity, sex, social contact, hunger, hierarchical status, and emotional state matching. Fiber photometry recordings and chemogenetic manipulations demonstrated that BLA neurons are involved in the establishment of prosocial decisions. In particular, BLA neurons projecting to the prelimbic region (PL) of the PFC mediated the development of a preference for altruistic choices, whereas PL projections to the BLA modulated self-interest motives on decision-making. This provides a neurobiological model of altruistic and selfish choices with relevance to pathologies associated with dysfunctions in social decision-making.
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Terms governing use and reproduction
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Terms governing use and reproduction https://www.springernature.com/gp/open-research/policies/accepted-manuscript-termsUsers may view, print, copy, and download text and data-mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use: https://www.springernature.com/gp/open-research/policies/accepted-manuscript-terms
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Language note en
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Topical term or geographic name as entry element Article
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Genre/form data or focus term Text
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Personal name La Greca, Filippo
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9 (RLIN) 1444
700 10 - ADDED ENTRY--PERSONAL NAME
Personal name Maltese, Federica
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9 (RLIN) 1445
700 10 - ADDED ENTRY--PERSONAL NAME
Personal name Chiacchierini, Giulia
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9 (RLIN) 1446
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Personal name Italia, Maria
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9 (RLIN) 1447
700 10 - ADDED ENTRY--PERSONAL NAME
Personal name Molent, Cinzia
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9 (RLIN) 1448
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Personal name Bernardi, Fabrizio
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9 (RLIN) 1449
700 10 - ADDED ENTRY--PERSONAL NAME
Personal name Coccia, Giulia
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9 (RLIN) 1450
700 10 - ADDED ENTRY--PERSONAL NAME
Personal name Carrano, Niccolò
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9 (RLIN) 1451
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Personal name Zianni, Elisa
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9 (RLIN) 1452
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Personal name Gardoni, Fabrizio
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9 (RLIN) 1453
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Personal name Diluca, Monica
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9 (RLIN) 1454
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Personal name Papaleo, Francesco
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9 (RLIN) 1455
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Note Nat Neurosci
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Uniform Resource Identifier <a href="http://dx.doi.org/10.1038/s41593-022-01179-2">http://dx.doi.org/10.1038/s41593-022-01179-2</a>
Public note Connect to this object online.

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