Empagliflozin in Patients with Chronic Kidney Disease (Record no. 2037)
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042 ## - AUTHENTICATION CODE | |
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Authentication code | dc |
245 00 - TITLE STATEMENT | |
Title | Empagliflozin in Patients with Chronic Kidney Disease |
260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
Date of publication, distribution, etc. | 2023-01-12. |
500 ## - GENERAL NOTE | |
General note | /pmc/articles/PMC7614055/ |
500 ## - GENERAL NOTE | |
General note | /pubmed/36331190 |
520 ## - SUMMARY, ETC. | |
Summary, etc. | BACKGROUND: This study, the EMPA-KIDNEY trial, was designed to assess the effects of empagliflozin in a broad range of patients with chronic kidney disease (CKD) at risk of progression. METHODS: We randomly assigned 6609 participants to empagliflozin (10mg once daily) versus matching placebo. Eligibility required an estimated glomerular filtration rate (eGFR) of ≥20 to <45 ml/minute/1.73m(2); or ≥45 to <90 ml/minute/1.73m(2) with a urinary albumin-to-creatinine ratio (ACR) of ≥200 mg/g. The primary outcome was a composite of kidney disease progression (end-stage kidney disease, a sustained eGFR <10 ml/minute/1.73m(2), a sustained decline in eGFR of ≥40%, or a renal death) or death from cardiovascular causes. RESULTS: During a median of 2.0 years follow-up, a primary outcome event occurred in 432 of 3304 patients (13.1%) in the empagliflozin group and in 558 of 3305 patients (16.9%) in the placebo group (hazard ratio, 0.72; 95% CI 0.64 to 0.82; P<0.001), with consistent results in those with or without diabetes and across the range of eGFR studied. There were fewer hospitalizations from any cause in the empagliflozin group (0.86; 0.78 to 0.95, P=0.003), but no statistically significant effect on hospitalization for heart failure or cardiovascular death (4.0% vs 4.6%), or death from any cause (4.5% vs 5.1%). The rates of serious adverse events were broadly similar in the two groups. CONCLUSIONS: Empagliflozin reduced the risk of the composite outcome of kidney disease progression or cardiovascular death in a wide range of patients at risk of CKD progression. (Funding:Boehringer Ingelheim, Eli Lilly and others; Clinicaltrials.gov:NCT03594110, EuDRACT: 2017-002971-24). |
540 ## - TERMS GOVERNING USE AND REPRODUCTION NOTE | |
Terms governing use and reproduction | |
540 ## - TERMS GOVERNING USE AND REPRODUCTION NOTE | |
Terms governing use and reproduction | https://creativecommons.org/licenses/by-nd/4.0/This work is licensed under a CC BY-ND 4.0 (https://creativecommons.org/licenses/by-nd/4.0/) International license. |
546 ## - LANGUAGE NOTE | |
Language note | en |
690 ## - LOCAL SUBJECT ADDED ENTRY--TOPICAL TERM (OCLC, RLIN) | |
Topical term or geographic name as entry element | Article |
655 7# - INDEX TERM--GENRE/FORM | |
Genre/form data or focus term | Text |
Source of term | local |
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Personal name | Herrington, William G. |
Relator term | author |
9 (RLIN) | 2196 |
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Personal name | Staplin, Natalie |
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Personal name | Wanner, Christoph |
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9 (RLIN) | 2198 |
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Personal name | Green, Jennifer B. |
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Personal name | Hauske, Sibylle J. |
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Personal name | Emberson, Jonathan R. |
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Personal name | Preiss, David |
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Personal name | Judge, Parminder |
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Personal name | Mayne, Kaitlin J. |
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Personal name | Ng, Sarah Y.A. |
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Personal name | Sammons, Emily |
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700 10 - ADDED ENTRY--PERSONAL NAME | |
Personal name | Zhu, Doreen |
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Personal name | Hill, Michael |
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700 10 - ADDED ENTRY--PERSONAL NAME | |
Personal name | Stevens, Will |
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Personal name | Wallendszus, Karl |
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Personal name | Brenner, Susanne |
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700 10 - ADDED ENTRY--PERSONAL NAME | |
Personal name | Cheung, Alfred K. |
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9 (RLIN) | 2212 |
700 10 - ADDED ENTRY--PERSONAL NAME | |
Personal name | Liu, Zhi-Hong |
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700 10 - ADDED ENTRY--PERSONAL NAME | |
Personal name | Li, Jing |
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700 10 - ADDED ENTRY--PERSONAL NAME | |
Personal name | Hooi, Lai Seong |
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700 10 - ADDED ENTRY--PERSONAL NAME | |
Personal name | Liu, Wen |
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9 (RLIN) | 2216 |
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Personal name | Kadowaki, Takashi |
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700 10 - ADDED ENTRY--PERSONAL NAME | |
Personal name | Nangaku, Masaomi |
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Personal name | Levin, Adeera |
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Personal name | Cherney, David |
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700 10 - ADDED ENTRY--PERSONAL NAME | |
Personal name | Maggioni, Aldo P. |
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Personal name | Pontremoli, Roberto |
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Personal name | Deo, Rajat |
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Personal name | Goto, Shinya |
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Personal name | Rossello, Xavier |
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9 (RLIN) | 2225 |
700 10 - ADDED ENTRY--PERSONAL NAME | |
Personal name | Tuttle, Katherine R. |
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9 (RLIN) | 2226 |
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Personal name | Steubl, Dominik |
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9 (RLIN) | 2227 |
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Personal name | Petrini, Michaela |
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9 (RLIN) | 2228 |
700 10 - ADDED ENTRY--PERSONAL NAME | |
Personal name | Massey, Dan |
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9 (RLIN) | 2229 |
700 10 - ADDED ENTRY--PERSONAL NAME | |
Personal name | Eilbracht, Jens |
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9 (RLIN) | 2230 |
700 10 - ADDED ENTRY--PERSONAL NAME | |
Personal name | Brueckmann, Martina |
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9 (RLIN) | 2231 |
700 10 - ADDED ENTRY--PERSONAL NAME | |
Personal name | Landray, Martin J. |
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9 (RLIN) | 2232 |
700 10 - ADDED ENTRY--PERSONAL NAME | |
Personal name | Baigent, Colin |
Relator term | author |
9 (RLIN) | 2233 |
700 10 - ADDED ENTRY--PERSONAL NAME | |
Personal name | Haynes, Richard |
Relator term | author |
9 (RLIN) | 2234 |
786 0# - DATA SOURCE ENTRY | |
Note | N Engl J Med |
856 41 - ELECTRONIC LOCATION AND ACCESS | |
Uniform Resource Identifier | <a href="http://dx.doi.org/10.1056/NEJMoa2204233">http://dx.doi.org/10.1056/NEJMoa2204233</a> |
Public note | Connect to this object online. |
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