Randomised controlled trial of the short-term effects of OROS-methylphenidate on ADHD symptoms and behavioural outcomes in young male prisoners with attention deficit hyperactivity disorder (CIAO-II) (Record no. 2039)
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042 ## - AUTHENTICATION CODE | |
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Authentication code | dc |
100 10 - MAIN ENTRY--PERSONAL NAME | |
Personal name | Asherson, P |
Relator term | author |
9 (RLIN) | 1771 |
245 00 - TITLE STATEMENT | |
Title | Randomised controlled trial of the short-term effects of OROS-methylphenidate on ADHD symptoms and behavioural outcomes in young male prisoners with attention deficit hyperactivity disorder (CIAO-II) |
260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
Date of publication, distribution, etc. | 2023-01. |
500 ## - GENERAL NOTE | |
General note | /pmc/articles/PMC7613969/ |
500 ## - GENERAL NOTE | |
General note | /pubmed/35657651 |
520 ## - SUMMARY, ETC. | |
Summary, etc. | BACKGROUND: 20-30% of prisoners meet diagnostic criteria for attention-deficit/hyperactivity disorder (ADHD). Methylphenidate reduces ADHD symptoms but effects in prisoners are uncertain due to comorbid mental health and substance use disorders. AIM: To estimate the efficacy of an Osmotic-Release-Oral-System methylphenidate (OROS-methylphenidate) in reducing ADHD symptoms in young adult prisoners with ADHD. METHODS: An 8-week parallel arm, double-blind, randomised, placebo-controlled trial of OROS-methylphenidate versus placebo in male prisoners (aged 16-25) meeting DSM-5 criteria for ADHD. Primary outcome was ADHD symptoms at 8-weeks using the investigator rated Connors Adult ADHD Rating Scale (CAARS-O). Thirteen secondary outcome measures included emotional dysregulation, mind-wandering, violent attitudes, mental health symptoms, and prison officer and educational staff ratings of behaviour and aggression. FINDINGS: Mean CAARS-O at 8 weeks in the OROS-methylphenidate arm was estimated to be reduced by 0.57 points relative to the Placebo arm (95% CI: -2.41 to 3.56) and non-significant. The responder rate, defined as a 20% reduction in CAARS-O scores was 48.3% for the OROS-methylphenidate arm and 47.9% for the placebo arm. No statistically significant trial arm differences were detected for any of the secondary outcomes. Mean final titrated dose was 53.8 mg in the OROS-methylphenidate arm. CONCLUSIONS: ADHD symptoms did not respond to OROS-methylphenidate in young adult prisoners. The findings do not support routine treatment with OROS-methylphenidate in this population. Further research is needed to evaluate effects of higher average dosing and adherence to treatment, multimodal treatments, and preventative interventions in the community. TRIAL REGISTRATION: EudraCT Number 2015-004271-78; ISRCTN16827947. Database lock 27(th) August 2019 |
540 ## - TERMS GOVERNING USE AND REPRODUCTION NOTE | |
Terms governing use and reproduction | |
546 ## - LANGUAGE NOTE | |
Language note | en |
690 ## - LOCAL SUBJECT ADDED ENTRY--TOPICAL TERM (OCLC, RLIN) | |
Topical term or geographic name as entry element | Article |
655 7# - INDEX TERM--GENRE/FORM | |
Genre/form data or focus term | Text |
Source of term | local |
700 10 - ADDED ENTRY--PERSONAL NAME | |
Personal name | Johansson, L |
Relator term | author |
9 (RLIN) | 1772 |
700 10 - ADDED ENTRY--PERSONAL NAME | |
Personal name | Holland, R |
Relator term | author |
9 (RLIN) | 1773 |
700 10 - ADDED ENTRY--PERSONAL NAME | |
Personal name | Bedding, M |
Relator term | author |
9 (RLIN) | 1774 |
700 10 - ADDED ENTRY--PERSONAL NAME | |
Personal name | Forrester, A |
Relator term | author |
9 (RLIN) | 1775 |
700 10 - ADDED ENTRY--PERSONAL NAME | |
Personal name | Giannulli, L |
Relator term | author |
9 (RLIN) | 1776 |
700 10 - ADDED ENTRY--PERSONAL NAME | |
Personal name | Ginsberg, Y |
Relator term | author |
9 (RLIN) | 1777 |
700 10 - ADDED ENTRY--PERSONAL NAME | |
Personal name | Howitt, S |
Relator term | author |
9 (RLIN) | 1778 |
700 10 - ADDED ENTRY--PERSONAL NAME | |
Personal name | Kretzschmar, I |
Relator term | author |
9 (RLIN) | 1779 |
700 10 - ADDED ENTRY--PERSONAL NAME | |
Personal name | Lawrie, SM |
Relator term | author |
9 (RLIN) | 1780 |
700 10 - ADDED ENTRY--PERSONAL NAME | |
Personal name | Marsh, C |
Relator term | author |
9 (RLIN) | 1781 |
700 10 - ADDED ENTRY--PERSONAL NAME | |
Personal name | Kelly, C |
Relator term | author |
9 (RLIN) | 1782 |
700 10 - ADDED ENTRY--PERSONAL NAME | |
Personal name | Mansfield, M |
Relator term | author |
9 (RLIN) | 1783 |
700 10 - ADDED ENTRY--PERSONAL NAME | |
Personal name | McCafferty, C |
Relator term | author |
9 (RLIN) | 1784 |
700 10 - ADDED ENTRY--PERSONAL NAME | |
Personal name | Khan, K |
Relator term | author |
9 (RLIN) | 1785 |
700 10 - ADDED ENTRY--PERSONAL NAME | |
Personal name | Muller-Sedgwick, U |
Relator term | author |
9 (RLIN) | 1786 |
700 10 - ADDED ENTRY--PERSONAL NAME | |
Personal name | Strang, J |
Relator term | author |
9 (RLIN) | 1787 |
700 10 - ADDED ENTRY--PERSONAL NAME | |
Personal name | Williamson, G |
Relator term | author |
9 (RLIN) | 1788 |
700 10 - ADDED ENTRY--PERSONAL NAME | |
Personal name | Wilson, L |
Relator term | author |
9 (RLIN) | 1789 |
700 10 - ADDED ENTRY--PERSONAL NAME | |
Personal name | Young, S |
Relator term | author |
9 (RLIN) | 1790 |
700 10 - ADDED ENTRY--PERSONAL NAME | |
Personal name | Landau, S |
Relator term | author |
9 (RLIN) | 1791 |
700 10 - ADDED ENTRY--PERSONAL NAME | |
Personal name | Thomson, L |
Relator term | author |
9 (RLIN) | 1792 |
786 0# - DATA SOURCE ENTRY | |
Note | Br J Psychiatry |
856 41 - ELECTRONIC LOCATION AND ACCESS | |
Uniform Resource Identifier | <a href="http://dx.doi.org/10.1192/bjp.2022.77">http://dx.doi.org/10.1192/bjp.2022.77</a> |
Public note | Connect to this object online. |
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