Robust Early Pregnancy Prediction of Later Preeclampsia Using Metabolomic Biomarkers (Record no. 2043)
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042 ## - AUTHENTICATION CODE | |
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Authentication code | dc |
100 10 - MAIN ENTRY--PERSONAL NAME | |
Personal name | Kenny, Louise C. |
Relator term | author |
9 (RLIN) | 2659 |
245 00 - TITLE STATEMENT | |
Title | Robust Early Pregnancy Prediction of Later Preeclampsia Using Metabolomic Biomarkers |
260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
Date of publication, distribution, etc. | 2010-10-01. |
500 ## - GENERAL NOTE | |
General note | /pmc/articles/PMC7614124/ |
500 ## - GENERAL NOTE | |
General note | /pubmed/20837882 |
520 ## - SUMMARY, ETC. | |
Summary, etc. | Preeclampsia is a pregnancy-specific syndrome that causes substantial maternal and fetal morbidity and mortality. The etiology is incompletely understood, and there is no clinically useful screening test. Current metabolomic technologies have allowed the establishment of metabolic signatures of preeclampsia in early pregnancy. Here, a 2-phase discovery/validation metabolic profiling study was performed. In the discovery phase, a nested case-control study was designed, using samples obtained at 15±1 weeks' gestation from 60 women who subsequently developed preeclampsia and 60 controls taking part in the prospective Screening for Pregnancy Endpoints cohort study. Controls were proportionally population matched for age, ethnicity, and body mass index at booking. Plasma samples were analyzed using ultra performance liquid chromatography-mass spectrometry. A multivariate predictive model combining 14 metabolites gave an odds ratio for developing preeclampsia of 36 (95% CI: 12 to 108), with an area under the receiver operator characteristic curve of 0.94. These findings were then validated using an independent case-control study on plasma obtained at 15±1 weeks from 39 women who subsequently developed preeclampsia and 40 similarly matched controls from a participating center in a different country. The same 14 metabolites produced an odds ratio of 23 (95% CI: 7 to 73) with an area under receiver operator characteristic curve of 0.92. The finding of a consistent discriminatory metabolite signature in early pregnancy plasma preceding the onset of preeclampsia offers insight into disease pathogenesis and offers the tantalizing promise of a robust presymptomatic screening test. (Hypertension. 2010;56:741-749.) |
540 ## - TERMS GOVERNING USE AND REPRODUCTION NOTE | |
Terms governing use and reproduction | |
546 ## - LANGUAGE NOTE | |
Language note | en |
690 ## - LOCAL SUBJECT ADDED ENTRY--TOPICAL TERM (OCLC, RLIN) | |
Topical term or geographic name as entry element | Article |
655 7# - INDEX TERM--GENRE/FORM | |
Genre/form data or focus term | Text |
Source of term | local |
700 10 - ADDED ENTRY--PERSONAL NAME | |
Personal name | Broadhurst, David I. |
Relator term | author |
9 (RLIN) | 2660 |
700 10 - ADDED ENTRY--PERSONAL NAME | |
Personal name | Dunn, Warwick |
Relator term | author |
9 (RLIN) | 2661 |
700 10 - ADDED ENTRY--PERSONAL NAME | |
Personal name | Brown, Marie |
Relator term | author |
9 (RLIN) | 2662 |
700 10 - ADDED ENTRY--PERSONAL NAME | |
Personal name | North, Robyn A. |
Relator term | author |
9 (RLIN) | 2663 |
700 10 - ADDED ENTRY--PERSONAL NAME | |
Personal name | McCowan, Lesley |
Relator term | author |
9 (RLIN) | 2664 |
700 10 - ADDED ENTRY--PERSONAL NAME | |
Personal name | Roberts, Claire |
Relator term | author |
9 (RLIN) | 2665 |
700 10 - ADDED ENTRY--PERSONAL NAME | |
Personal name | Cooper, Garth J.S. |
Relator term | author |
9 (RLIN) | 2666 |
700 10 - ADDED ENTRY--PERSONAL NAME | |
Personal name | Kell, Douglas B. |
Relator term | author |
9 (RLIN) | 2667 |
700 10 - ADDED ENTRY--PERSONAL NAME | |
Personal name | Baker, Philip N. |
Relator term | author |
9 (RLIN) | 2668 |
786 0# - DATA SOURCE ENTRY | |
Note | Hypertension |
856 41 - ELECTRONIC LOCATION AND ACCESS | |
Uniform Resource Identifier | <a href="http://dx.doi.org/10.1161/HYPERTENSIONAHA.110.157297">http://dx.doi.org/10.1161/HYPERTENSIONAHA.110.157297</a> |
Public note | Connect to this object online. |
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