JOM KITA KE POLITEKNIK

Advances in methods to analyse cardiolipin and their clinical applications (Record no. 2105)

MARC details
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Personal name Bautista, Javier S.
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9 (RLIN) 2814
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Title Advances in methods to analyse cardiolipin and their clinical applications
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Date of publication, distribution, etc. 2022-12.
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General note /pmc/articles/PMC7614147/
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General note /pubmed/36751553
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Summary, etc. Cardiolipin (CL) is a mitochondria-exclusive phospholipid, primarily localised within the inner mitochondrial membrane, that plays an essential role in mitochondrial architecture and function. Aberrant CL content, structure, and localisation have all been linked to impaired mitochondrial activity and are observed in the pathophysiology of cancer and neurological, cardiovascular, and metabolic disorders. The detection, quantification, and localisation of CL species is a valuable tool to investigate mitochondrial dysfunction and the pathophysiological mechanisms underpinning several human disorders. CL is measured using liquid chromatography, usually combined with mass spectrometry, mass spectrometry imaging, shotgun lipidomics, ion mobility spectrometry, fluorometry, and radiolabelling. This review summarises available methods to analyse CL, with a particular focus on modern mass spectrometry, and evaluates their advantages and limitations. We provide guidance aimed at selecting the most appropriate technique, or combination of techniques, when analysing CL in different model systems, and highlight the clinical contexts in which measuring CL is relevant.
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Terms governing use and reproduction
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Terms governing use and reproduction https://creativecommons.org/licenses/by/4.0/This work is licensed under a CC BY 4.0 (https://creativecommons.org/licenses/by/4.0/) International license.
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Language note en
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Topical term or geographic name as entry element Article
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Genre/form data or focus term Text
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Personal name Falabella, Micol
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9 (RLIN) 2815
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Personal name Flannery, Padraig J.
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9 (RLIN) 2816
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Personal name Hanna, Michael G.
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9 (RLIN) 2817
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Personal name Heales, Simon J.R.
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9 (RLIN) 2818
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Personal name Pope, Simon A.S.
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9 (RLIN) 2819
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Personal name Pitceathly, Robert D.S.
Relator term author
9 (RLIN) 2820
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Note Trends Analyt Chem
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Uniform Resource Identifier <a href="http://dx.doi.org/10.1016/j.trac.2022.116808">http://dx.doi.org/10.1016/j.trac.2022.116808</a>
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