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Childhood maltreatment and mental health problems: A systematic review and meta-analysis of quasi-experimental studies (Record no. 2126)

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Personal name Baldwin, Jessie R.
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9 (RLIN) 2866
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Title Childhood maltreatment and mental health problems: A systematic review and meta-analysis of quasi-experimental studies
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Date of publication, distribution, etc. 2023-02-01.
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General note /pmc/articles/PMC7614155/
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General note /pubmed/36628513
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Summary, etc. OBJECTIVE: Childhood maltreatment is associated with mental health problems, but the extent to which this relationship is causal remains unclear. To strengthen causal inference, we conducted a systematic review and meta-analysis of quasi-experimental studies examining the relationship between childhood maltreatment and mental health problems. METHODS: We searched PubMed, PsycINFO, and Embase for peer-reviewed, English language articles from inception until January 1, 2022. Studies were included if they examined the association between childhood maltreatment and mental health problems using a quasi-experimental method (e.g., twin/sibling differences design, Children of Twins design, adoption design, fixed-effects design, random-intercept cross-lagged panel model, natural experiment, propensity score matching, or inverse probability weighting). RESULTS: We identified 34 quasi-experimental studies, including 54,646 independent participants. Before quasi-experimental adjustment for confounding, childhood maltreatment was moderately associated with mental health problems (Cohen's d=0.56, 95% CI=0.41-0.71). Following quasi-experimental adjustment, a small association between childhood maltreatment and mental health problems remained (Cohen's d=0.31, 95% CI=0.24-0.37). This adjusted association between child maltreatment and mental health was consistent across different quasi-experimental methods, and generalised across different psychiatric disorders. CONCLUSION: These findings are consistent with a small, causal contribution of childhood maltreatment to mental health problems. Furthermore, the findings suggest that part of the overall risk of mental health problems in individuals exposed to maltreatment is due to wider genetic and environmental risk factors. Therefore, preventing childhood maltreatment and addressing wider psychiatric risk factors in individuals exposed to maltreatment could help to prevent psychopathology.
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Terms governing use and reproduction
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Terms governing use and reproduction https://creativecommons.org/licenses/by/4.0/This work is licensed under a CC BY 4.0 (https://creativecommons.org/licenses/by/4.0/) International license.
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Language note en
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Topical term or geographic name as entry element Article
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Genre/form data or focus term Text
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Personal name Wang, Biyao
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9 (RLIN) 2867
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Personal name Karwatowska, Lucy
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9 (RLIN) 2868
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Personal name Schoeler, Tabea
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9 (RLIN) 2869
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Personal name Tsaligopoulou, Anna
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9 (RLIN) 2870
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Personal name Munafò, Marcus R.
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9 (RLIN) 1924
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Personal name Pingault, Jean-Baptiste
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9 (RLIN) 2871
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Note Am J Psychiatry
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Uniform Resource Identifier <a href="http://dx.doi.org/10.1176/appi.ajp.20220174">http://dx.doi.org/10.1176/appi.ajp.20220174</a>
Public note Connect to this object online.

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