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Head-to-tail polymerization by VEL proteins underpins cold-induced Polycomb silencing in flowering control (Record no. 2138)

MARC details
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Authentication code dc
100 10 - MAIN ENTRY--PERSONAL NAME
Personal name Fiedler, Marc
Relator term author
9 (RLIN) 2461
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Title Head-to-tail polymerization by VEL proteins underpins cold-induced Polycomb silencing in flowering control
260 ## - PUBLICATION, DISTRIBUTION, ETC.
Name of publisher, distributor, etc. Cell Press,
Date of publication, distribution, etc. 2022-11-08.
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General note /pmc/articles/PMC7614096/
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General note /pubmed/36351412
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Summary, etc. Transcriptional silencing through the Polycomb silencing machinery utilizes a "read-write" mechanism involving histone tail modifications. However, nucleation of silencing and long-term stable transmission of the silenced state also requires P-olycomb Repressive Complex 2 (PRC2) accessory proteins, whose molecular role is poorly understood. The Arabidopsis VEL proteins are accessory proteins that interact with PRC2 to nucleate and propagate silencing at the FLOWERING LOCUS C (FLC) locus, enabling early flowering in spring. Here, we report that VEL proteins contain a domain related to an atypical four-helix bundle that engages in spontaneous concentration-dependent head-to-tail polymerization to assemble dynamic biomolecular condensates. Mutations blocking polymerization of this VEL domain prevent Polycomb silencing at FLC. Plant VEL proteins thus facilitate assembly of dynamic multivalent Polycomb complexes required for inheritance of the silenced state.
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Terms governing use and reproduction Crown Copyright © 2022.
540 ## - TERMS GOVERNING USE AND REPRODUCTION NOTE
Terms governing use and reproduction https://creativecommons.org/licenses/by/4.0/This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
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Language note en
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Topical term or geographic name as entry element Article
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Genre/form data or focus term Text
Source of term local
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Personal name Franco-Echevarría, Elsa
Relator term author
9 (RLIN) 2462
700 10 - ADDED ENTRY--PERSONAL NAME
Personal name Schulten, Anna
Relator term author
9 (RLIN) 2463
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Personal name Nielsen, Mathias
Relator term author
9 (RLIN) 2464
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Personal name Rutherford, Trevor J.
Relator term author
9 (RLIN) 2465
700 10 - ADDED ENTRY--PERSONAL NAME
Personal name Yeates, Anna
Relator term author
9 (RLIN) 2466
700 10 - ADDED ENTRY--PERSONAL NAME
Personal name Ahsan, Bilal
Relator term author
9 (RLIN) 2467
700 10 - ADDED ENTRY--PERSONAL NAME
Personal name Dean, Caroline
Relator term author
9 (RLIN) 2468
700 10 - ADDED ENTRY--PERSONAL NAME
Personal name Bienz, Mariann
Relator term author
9 (RLIN) 2469
786 0# - DATA SOURCE ENTRY
Note Cell Rep
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Uniform Resource Identifier <a href="http://dx.doi.org/10.1016/j.celrep.2022.111607">http://dx.doi.org/10.1016/j.celrep.2022.111607</a>
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