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Best Practice Research Clinical Endocrinology and Metabolism Epigenetic Regulation of Bone Mass (Record no. 2172)

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Personal name Curtis, Elizabeth M
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Title Best Practice Research Clinical Endocrinology and Metabolism Epigenetic Regulation of Bone Mass
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Date of publication, distribution, etc. 2022-03-01.
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General note /pmc/articles/PMC7614112/
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General note /pubmed/35120798
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Summary, etc. Osteoporosis, characterised by low bone mass, poor bone structure, and an increased risk of fracture, is a major public health problem. There is increasing evidence that the influence of the environment on gene expression, through epigenetic processes, contributes to variation in BMD and fracture risk across the lifecourse. Such epigenetic processes include DNA methylation, histone and chromatin modifications and non-coding RNAs. Examples of associations with phenotype include DNA methylation in utero linked to maternal vitamin D status, and to methylation of target genes such as OPG and RANKL being associated with osteoporosis in later life. Epigenome-wide association studies and multi-omics technologies have further revealed susceptibility loci, and histone acetyltransferases, deacetylases and methylases are being considered as therapeutic targets. This review encompasses recent advances in our understanding of epigenetic mechanisms in the regulation of bone mass and osteoporosis development, and outlines possible diagnostic and prognostic biomarker applications.
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Language note en
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Topical term or geographic name as entry element Article
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700 10 - ADDED ENTRY--PERSONAL NAME
Personal name Fuggle, Nicholas R
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9 (RLIN) 2542
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Personal name Cooper, Cyrus
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Personal name Harvey, Nicholas C
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Note Best Pract Res Clin Endocrinol Metab
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Uniform Resource Identifier <a href="http://dx.doi.org/10.1016/j.beem.2021.101612">http://dx.doi.org/10.1016/j.beem.2021.101612</a>
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