NOTCH dependent cooperativity between myeloid lineages promotes Langerhans cell histiocytosis pathology (Record no. 2194)
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042 ## - AUTHENTICATION CODE | |
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Authentication code | dc |
100 10 - MAIN ENTRY--PERSONAL NAME | |
Personal name | Kvedaraite, Egle |
Relator term | author |
9 (RLIN) | 2596 |
245 00 - TITLE STATEMENT | |
Title | NOTCH dependent cooperativity between myeloid lineages promotes Langerhans cell histiocytosis pathology |
260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
Date of publication, distribution, etc. | 2022-12-23. |
500 ## - GENERAL NOTE | |
General note | /pmc/articles/PMC7614120/ |
500 ## - GENERAL NOTE | |
General note | /pubmed/36525505 |
520 ## - SUMMARY, ETC. | |
Summary, etc. | Langerhans cell histiocytosis (LCH) is a potentially fatal neoplasm, characterized by the aberrant differentiation of mononuclear phagocytes, driven by mitogen-activated protein kinase pathway activation. LCH cells may trigger destructive pathology yet remain in precarious state, finely balanced between apoptosis and survival, supported by a unique inflammatory milieu. The interactions that maintain this state are not well-known and may offer targets for intervention. Here, we used single-cell RNA-seq and protein analysis to dissect LCH lesions, assessing LCH cell heterogeneity, and comparing LCH cells with normal MNPs within lesions. We found LCH-discriminatory signatures pointing to senescence and escape from tumor immune surveillance. We also uncovered two major lineages of LCH with DC2- and DC3/Monocyte-like phenotypes and validated them in multiple pathological tissue sites by high-content imaging. Receptor-ligand analyses and lineage tracing in vitro revealed Notch dependent cooperativity between DC2 and DC3/monocyte lineages, during expression of the pathognomonic LCH program. Our results present a convergent dual origin model of LCH with MAPK pathway activation occurring prior to fate commitment to DC2 and DC3/Monocyte lineages and Notch-dependent cooperativity between lineages driving the development of LCH cells. |
540 ## - TERMS GOVERNING USE AND REPRODUCTION NOTE | |
Terms governing use and reproduction | |
540 ## - TERMS GOVERNING USE AND REPRODUCTION NOTE | |
Terms governing use and reproduction | https://creativecommons.org/licenses/by/4.0/This work is licensed under a CC BY 4.0 (https://creativecommons.org/licenses/by/4.0/) International license. |
546 ## - LANGUAGE NOTE | |
Language note | en |
690 ## - LOCAL SUBJECT ADDED ENTRY--TOPICAL TERM (OCLC, RLIN) | |
Topical term or geographic name as entry element | Article |
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Genre/form data or focus term | Text |
Source of term | local |
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Personal name | Milne, Paul |
Relator term | author |
9 (RLIN) | 2597 |
700 10 - ADDED ENTRY--PERSONAL NAME | |
Personal name | Khalilnezhad, Ahad |
Relator term | author |
9 (RLIN) | 2598 |
700 10 - ADDED ENTRY--PERSONAL NAME | |
Personal name | Chevrier, Marion |
Relator term | author |
9 (RLIN) | 2599 |
700 10 - ADDED ENTRY--PERSONAL NAME | |
Personal name | Sethi, Raman |
Relator term | author |
9 (RLIN) | 2600 |
700 10 - ADDED ENTRY--PERSONAL NAME | |
Personal name | Lee, Hong Kai |
Relator term | author |
9 (RLIN) | 2601 |
700 10 - ADDED ENTRY--PERSONAL NAME | |
Personal name | Hagey, Daniel W. |
Relator term | author |
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700 10 - ADDED ENTRY--PERSONAL NAME | |
Personal name | von Bahr Greenwood, Tatiana |
Relator term | author |
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Personal name | Mouratidou, Natalia |
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Personal name | Jädersten, Martin |
Relator term | author |
9 (RLIN) | 2605 |
700 10 - ADDED ENTRY--PERSONAL NAME | |
Personal name | Lee, Nicole Yee Shin |
Relator term | author |
9 (RLIN) | 2606 |
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Personal name | Minnerup, Lara |
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700 10 - ADDED ENTRY--PERSONAL NAME | |
Personal name | Yingrou, Tan |
Relator term | author |
9 (RLIN) | 2608 |
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Personal name | Dutertre, Charles-Antoine |
Relator term | author |
9 (RLIN) | 2609 |
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Personal name | Benac, Nathan |
Relator term | author |
9 (RLIN) | 2610 |
700 10 - ADDED ENTRY--PERSONAL NAME | |
Personal name | Hwang, You Yi |
Relator term | author |
9 (RLIN) | 2611 |
700 10 - ADDED ENTRY--PERSONAL NAME | |
Personal name | Lum, Josephine |
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700 10 - ADDED ENTRY--PERSONAL NAME | |
Personal name | Loh, Amos Hong Pheng |
Relator term | author |
9 (RLIN) | 2613 |
700 10 - ADDED ENTRY--PERSONAL NAME | |
Personal name | Jansson, Jessica |
Relator term | author |
9 (RLIN) | 2614 |
700 10 - ADDED ENTRY--PERSONAL NAME | |
Personal name | Teng, Karen Wei Weng |
Relator term | author |
9 (RLIN) | 2615 |
700 10 - ADDED ENTRY--PERSONAL NAME | |
Personal name | Khalilnezhad, Shabnam |
Relator term | author |
9 (RLIN) | 2616 |
700 10 - ADDED ENTRY--PERSONAL NAME | |
Personal name | Weili, Xu |
Relator term | author |
9 (RLIN) | 2617 |
700 10 - ADDED ENTRY--PERSONAL NAME | |
Personal name | Resteu, Anastasia |
Relator term | author |
9 (RLIN) | 2618 |
700 10 - ADDED ENTRY--PERSONAL NAME | |
Personal name | Liang, Tey Hong |
Relator term | author |
9 (RLIN) | 2619 |
700 10 - ADDED ENTRY--PERSONAL NAME | |
Personal name | Guan, Ng Lai |
Relator term | author |
9 (RLIN) | 2620 |
700 10 - ADDED ENTRY--PERSONAL NAME | |
Personal name | Larbi, Anis |
Relator term | author |
9 (RLIN) | 2621 |
700 10 - ADDED ENTRY--PERSONAL NAME | |
Personal name | Howland, Shanshan Wu |
Relator term | author |
9 (RLIN) | 2622 |
700 10 - ADDED ENTRY--PERSONAL NAME | |
Personal name | Arnell, Henrik |
Relator term | author |
9 (RLIN) | 2623 |
700 10 - ADDED ENTRY--PERSONAL NAME | |
Personal name | Andaloussi, Samir EL |
Relator term | author |
9 (RLIN) | 2624 |
700 10 - ADDED ENTRY--PERSONAL NAME | |
Personal name | Braier, Jorge |
Relator term | author |
9 (RLIN) | 2625 |
700 10 - ADDED ENTRY--PERSONAL NAME | |
Personal name | Rassidakis, Georgios |
Relator term | author |
9 (RLIN) | 2626 |
700 10 - ADDED ENTRY--PERSONAL NAME | |
Personal name | Galluzzo, Laura |
Relator term | author |
9 (RLIN) | 2627 |
700 10 - ADDED ENTRY--PERSONAL NAME | |
Personal name | Dzionek, Andrzej |
Relator term | author |
9 (RLIN) | 2628 |
700 10 - ADDED ENTRY--PERSONAL NAME | |
Personal name | Henter, Jan-Inge |
Relator term | author |
9 (RLIN) | 2629 |
700 10 - ADDED ENTRY--PERSONAL NAME | |
Personal name | Chen, Jinmiao |
Relator term | author |
9 (RLIN) | 2630 |
700 10 - ADDED ENTRY--PERSONAL NAME | |
Personal name | Collin, Matthew |
Relator term | author |
9 (RLIN) | 2631 |
700 10 - ADDED ENTRY--PERSONAL NAME | |
Personal name | Ginhoux, Florent |
Relator term | author |
9 (RLIN) | 2632 |
786 0# - DATA SOURCE ENTRY | |
Note | Sci Immunol |
856 41 - ELECTRONIC LOCATION AND ACCESS | |
Uniform Resource Identifier | <a href="http://dx.doi.org/10.1126/sciimmunol.add3330">http://dx.doi.org/10.1126/sciimmunol.add3330</a> |
Public note | Connect to this object online. |
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