JOM KITA KE POLITEKNIK

Tissue Engineering Cartilage with Deep Zone Cytoarchitecture by High-Resolution Acoustic Cell Patterning (Record no. 2229)

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Personal name Armstrong, James P. K.
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9 (RLIN) 2288
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Title Tissue Engineering Cartilage with Deep Zone Cytoarchitecture by High-Resolution Acoustic Cell Patterning
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Date of publication, distribution, etc. 2022-07-11.
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General note /pmc/articles/PMC7614068/
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General note /pubmed/35815530
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Summary, etc. The ultimate objective of tissue engineering is to fabricate artificial living constructs with a structural organization and function that faithfully resembles their native tissue counterparts. For example, the deep zone of articular cartilage possesses a distinctive anisotropic architecture with chondrocytes organized in aligned arrays ≈1-2 cells wide, features that are oriented parallel to surrounding extracellular matrix fibers and orthogonal to the underlying subchondral bone. Although there are major advances in fabricating custom tissue architectures, it remains a significant technical challenge to precisely recreate such fine cellular features in vitro. Here, it is shown that ultrasound standing waves can be used to remotely organize living chondrocytes into high-resolution anisotropic arrays, distributed throughout the full volume of agarose hydrogels. It is demonstrated that this cytoarchitecture is maintained throughout a five-week course of in vitro tissue engineering, producing hyaline cartilage with cellular and extracellular matrix organization analogous to the deep zone of native articular cartilage. It is anticipated that this acoustic cell patterning method will provide unprecedented opportunities to interrogate in vitro the contribution of chondrocyte organization to the development of aligned extracellular matrix fibers, and ultimately, the design of new mechanically anisotropic tissue grafts for articular cartilage regeneration.
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Terms governing use and reproduction
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Terms governing use and reproduction https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. (https://creativecommons.org/licenses/by/4.0/)
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Language note en
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Topical term or geographic name as entry element Article
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Genre/form data or focus term Text
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Personal name Pchelintseva, Ekaterina
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9 (RLIN) 2289
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Personal name Treumuth, Sirli
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9 (RLIN) 2290
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Personal name Campanella, Cristiana
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9 (RLIN) 2291
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Personal name Meinert, Christoph
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9 (RLIN) 2292
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Personal name Klein, Travis J.
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9 (RLIN) 2293
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Personal name Hutmacher, Dietmar W.
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9 (RLIN) 2294
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Personal name Drinkwater, Bruce W.
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9 (RLIN) 2295
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Personal name Stevens, Molly M.
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Note Adv Healthc Mater
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Uniform Resource Identifier <a href="http://dx.doi.org/10.1002/adhm.202200481">http://dx.doi.org/10.1002/adhm.202200481</a>
Public note Connect to this object online.

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