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Mechanical stress driven by rigidity sensing governs epithelial stability (Record no. 2243)

MARC details
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Personal name Sonam, Surabhi
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9 (RLIN) 2319
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Title Mechanical stress driven by rigidity sensing governs epithelial stability
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Date of publication, distribution, etc. 2023-01.
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General note /pmc/articles/PMC7614076/
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General note /pubmed/36686215
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Summary, etc. Epithelia act as a barrier against environmental stress and abrasion and in vivo they are continuously exposed to environments of various mechanical properties. The impact of this environment on epithelial integrity remains elusive. By culturing epithelial cells on 2D hydrogels, we observe a loss of epithelial monolayer integrity through spontaneous hole formation when grown on soft substrates. Substrate stiffness triggers an unanticipated mechanical switch of epithelial monolayers from tensile on soft to compressive on stiff substrates. Through active nematic modelling, we find that spontaneous half-integer defect formation underpinning large isotropic stress fluctuations initiate hole opening events. Our data show that monolayer rupture due to high tensile stress is promoted by the weakening of cell-cell junctions that could be induced by cell division events or local cellular stretching. Our results show that substrate stiffness provides feedback on monolayer mechanical state and that topological defects can trigger stochastic mechanical failure, with potential application towards a mechanistic understanding of compromised epithelial integrity during immune response and morphogenesis.
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Terms governing use and reproduction
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Terms governing use and reproduction https://www.springernature.com/gp/open-research/policies/accepted-manuscript-termsUsers may view, print, copy, and download text and data-mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use: https://www.springernature.com/gp/open-research/policies/accepted-manuscript-terms
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Language note en
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Topical term or geographic name as entry element Article
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Genre/form data or focus term Text
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Personal name Balasubramaniam, Lakshmi
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9 (RLIN) 2320
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Personal name Lin, Shao-Zhen
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9 (RLIN) 2321
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Personal name Ivan, Ying Ming Yow
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9 (RLIN) 2322
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Personal name Jaumà, Irina Pi
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9 (RLIN) 2323
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Personal name Jebane, Cecile
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9 (RLIN) 2324
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Personal name Karnat, Marc
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9 (RLIN) 2325
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Personal name Toyama, Yusuke
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9 (RLIN) 2326
700 10 - ADDED ENTRY--PERSONAL NAME
Personal name Marcq, Philippe
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9 (RLIN) 2327
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Personal name Prost, Jacques
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9 (RLIN) 2328
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Personal name Mège, René-Marc
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9 (RLIN) 2329
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Personal name Rupprecht, Jean-François
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9 (RLIN) 2330
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Personal name Ladoux, Benoît
Relator term author
9 (RLIN) 2331
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Note Nat Phys
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Uniform Resource Identifier <a href="http://dx.doi.org/10.1038/s41567-022-01826-2">http://dx.doi.org/10.1038/s41567-022-01826-2</a>
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