JOM KITA KE POLITEKNIK

Uncovering the source of mitochondrial superoxide in pro-inflammatory macrophages: Insights from immunometabolism (Record no. 2252)

MARC details
042 ## - AUTHENTICATION CODE
Authentication code dc
100 10 - MAIN ENTRY--PERSONAL NAME
Personal name Casey, Alva M.
Relator term author
9 (RLIN) 3172
245 00 - TITLE STATEMENT
Title Uncovering the source of mitochondrial superoxide in pro-inflammatory macrophages: Insights from immunometabolism
260 ## - PUBLICATION, DISTRIBUTION, ETC.
Date of publication, distribution, etc. 2022-10-01.
500 ## - GENERAL NOTE
General note /pmc/articles/PMC7614207/
500 ## - GENERAL NOTE
General note /pubmed/35792320
520 ## - SUMMARY, ETC.
Summary, etc. Mitochondrial-derived reactive oxygen species are important as antimicrobial agents and redox signals in pro-inflammatory macrophages. Macrophages produce superoxide in response to the TLR4 ligand LPS. However, the mechanism of LPS-induced superoxide generation is not fully understood. Superoxide is produced at complex I and complex III of the electron transport chain. Production of superoxide at either of these sites is highly dependent on the metabolic state of the cell which is dramatically altered by TLR4-induced metabolic reprogramming. This review will outline how metabolism impacts superoxide production in LPS-activated macrophages downstream of TLR4 signalling and address outstanding questions in this field.
540 ## - TERMS GOVERNING USE AND REPRODUCTION NOTE
Terms governing use and reproduction
540 ## - TERMS GOVERNING USE AND REPRODUCTION NOTE
Terms governing use and reproduction https://creativecommons.org/licenses/by/4.0/This work is licensed under a CC BY 4.0 (https://creativecommons.org/licenses/by/4.0/) International license.
546 ## - LANGUAGE NOTE
Language note en
690 ## - LOCAL SUBJECT ADDED ENTRY--TOPICAL TERM (OCLC, RLIN)
Topical term or geographic name as entry element Article
655 7# - INDEX TERM--GENRE/FORM
Genre/form data or focus term Text
Source of term local
700 10 - ADDED ENTRY--PERSONAL NAME
Personal name Murphy, Michael P.
Relator term author
9 (RLIN) 3173
786 0# - DATA SOURCE ENTRY
Note Biochim Biophys Acta Mol Basis Dis
856 41 - ELECTRONIC LOCATION AND ACCESS
Uniform Resource Identifier <a href="http://dx.doi.org/10.1016/j.bbadis.2022.166481">http://dx.doi.org/10.1016/j.bbadis.2022.166481</a>
Public note Connect to this object online.

No items available.