JOM KITA KE POLITEKNIK

Stable, interactive modulation of neuronal oscillations produced through brain-machine equilibrium (Record no. 2256)

MARC details
042 ## - AUTHENTICATION CODE
Authentication code dc
100 10 - MAIN ENTRY--PERSONAL NAME
Personal name McNamara, Colin G.
Relator term author
9 (RLIN) 2355
245 00 - TITLE STATEMENT
Title Stable, interactive modulation of neuronal oscillations produced through brain-machine equilibrium
260 ## - PUBLICATION, DISTRIBUTION, ETC.
Date of publication, distribution, etc. 2022-11-08.
500 ## - GENERAL NOTE
General note /pmc/articles/PMC7614081/
500 ## - GENERAL NOTE
General note /pubmed/36351413
520 ## - SUMMARY, ETC.
Summary, etc. Closed-loop interaction has the potential to regulate ongoing brain activity by continuously binding an external stimulation to specific dynamics of a neural circuit. Achieving interactive modulation requires a stable brain-machine feedback loop. Here, we demonstrate that it is possible to maintain oscillatory brain activity in a desired state by delivering stimulation accurately aligned with the timing of each cycle. We develop a fast algorithm that responds on a cycle-by-cycle basis to stimulate basal ganglia nuclei at predetermined phases of successive cortical beta cycles in parkinsonian rats. Using this approach, an equilibrium emerges between the modified brain signal and feedback-dependent stimulation pattern, leading to sustained amplification or suppression of the oscillation depending on the phase targeted. Beta amplification slows movement speed by biasing the animal's mode of locomotion. Together, these findings show that highly responsive, phase-dependent stimulation can achieve a stable brain-machine interaction that leads to robust modulation of ongoing behavior.
540 ## - TERMS GOVERNING USE AND REPRODUCTION NOTE
Terms governing use and reproduction
540 ## - TERMS GOVERNING USE AND REPRODUCTION NOTE
Terms governing use and reproduction https://creativecommons.org/licenses/by/4.0/This work is licensed under a CC BY 4.0 (https://creativecommons.org/licenses/by/4.0/) International license.
546 ## - LANGUAGE NOTE
Language note en
690 ## - LOCAL SUBJECT ADDED ENTRY--TOPICAL TERM (OCLC, RLIN)
Topical term or geographic name as entry element Article
655 7# - INDEX TERM--GENRE/FORM
Genre/form data or focus term Text
Source of term local
700 10 - ADDED ENTRY--PERSONAL NAME
Personal name Rothwell, Max
Relator term author
9 (RLIN) 2356
700 10 - ADDED ENTRY--PERSONAL NAME
Personal name Sharott, Andrew
Relator term author
9 (RLIN) 2357
786 0# - DATA SOURCE ENTRY
Note Cell Rep
856 41 - ELECTRONIC LOCATION AND ACCESS
Uniform Resource Identifier <a href="http://dx.doi.org/10.1016/j.celrep.2022.111616">http://dx.doi.org/10.1016/j.celrep.2022.111616</a>
Public note Connect to this object online.

No items available.