Identification of aceNKPs, a committed common progenitor population of the ILC1 and NK cell continuum (Record no. 426)
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042 ## - AUTHENTICATION CODE | |
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Authentication code | dc |
100 10 - MAIN ENTRY--PERSONAL NAME | |
Personal name | Rodriguez-Rodriguez, Noe |
Relator term | author |
9 (RLIN) | 2443 |
245 00 - TITLE STATEMENT | |
Title | Identification of aceNKPs, a committed common progenitor population of the ILC1 and NK cell continuum |
260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
Name of publisher, distributor, etc. | National Academy of Sciences, |
Date of publication, distribution, etc. | 2022-11-29. |
500 ## - GENERAL NOTE | |
General note | /pmc/articles/PMC7614094/ |
500 ## - GENERAL NOTE | |
General note | /pubmed/36442116 |
520 ## - SUMMARY, ETC. | |
Summary, etc. | The development of innate lymphoid cell (ILC) transcription factor reporter mice has shown a previously unexpected complexity in ILC hematopoiesis. Using novel polychromic mice to achieve higher phenotypic resolution, we have characterized bone marrow progenitors that are committed to the group 1 ILC lineage. These common ILC1/NK cell progenitors (ILC1/NKP), which we call "aceNKPs", are defined as lineage(-)Id2(+)IL-7Rα(+)CD25(-)α4β7(-)NKG2A/C/E(+)Bcl11b(-). In vitro, aceNKPs differentiate into group 1 ILCs, including NK-like cells that express Eomes without the requirement for IL-15, and produce IFN-γ and perforin upon IL-15 stimulation. Following reconstitution of Rag2(-/-)Il2rg(-/-) hosts, aceNKPs give rise to a spectrum of mature ILC1/NK cells (regardless of their tissue location) that cannot be clearly segregated into the traditional ILC1 and NK subsets, suggesting that group 1 ILCs constitute a dynamic continuum of ILCs that can develop from a common progenitor. In addition, aceNKP-derived ILC1/NK cells effectively ameliorate tumor burden in a model of lung metastasis, where they acquired a cytotoxic NK cell phenotype. Our results identify the primary ILC1/NK progenitor that lacks ILC2 or ILC3 potential and is strictly committed to ILC1/NK cell production irrespective of tissue homing. |
540 ## - TERMS GOVERNING USE AND REPRODUCTION NOTE | |
Terms governing use and reproduction | Copyright © 2022 the Author(s). Published by PNAS. |
540 ## - TERMS GOVERNING USE AND REPRODUCTION NOTE | |
Terms governing use and reproduction | https://creativecommons.org/licenses/by/4.0/This open access article is distributed under Creative Commons Attribution License 4.0 (CC BY) (https://creativecommons.org/licenses/by/4.0/) . |
546 ## - LANGUAGE NOTE | |
Language note | en |
690 ## - LOCAL SUBJECT ADDED ENTRY--TOPICAL TERM (OCLC, RLIN) | |
Topical term or geographic name as entry element | Biological Sciences |
9 (RLIN) | 2451 |
655 7# - INDEX TERM--GENRE/FORM | |
Genre/form data or focus term | Text |
Source of term | local |
700 10 - ADDED ENTRY--PERSONAL NAME | |
Personal name | Clark, Paula A. |
Relator term | author |
9 (RLIN) | 1961 |
700 10 - ADDED ENTRY--PERSONAL NAME | |
Personal name | Gogoi, Mayuri |
Relator term | author |
9 (RLIN) | 2444 |
700 10 - ADDED ENTRY--PERSONAL NAME | |
Personal name | Ferreira, Ana C. F. |
Relator term | author |
9 (RLIN) | 1959 |
700 10 - ADDED ENTRY--PERSONAL NAME | |
Personal name | Kerscher, Bernhard |
Relator term | author |
9 (RLIN) | 2445 |
700 10 - ADDED ENTRY--PERSONAL NAME | |
Personal name | Crisp, Alastair |
Relator term | author |
9 (RLIN) | 1964 |
700 10 - ADDED ENTRY--PERSONAL NAME | |
Personal name | Jolin, Helen E. |
Relator term | author |
9 (RLIN) | 1965 |
700 10 - ADDED ENTRY--PERSONAL NAME | |
Personal name | Murphy, Jane E. |
Relator term | author |
9 (RLIN) | 2446 |
700 10 - ADDED ENTRY--PERSONAL NAME | |
Personal name | Sivasubramaniam, Meera |
Relator term | author |
9 (RLIN) | 1962 |
700 10 - ADDED ENTRY--PERSONAL NAME | |
Personal name | Pedro, Luisa |
Relator term | author |
9 (RLIN) | 2447 |
700 10 - ADDED ENTRY--PERSONAL NAME | |
Personal name | Walker, Jennifer A. |
Relator term | author |
9 (RLIN) | 2448 |
700 10 - ADDED ENTRY--PERSONAL NAME | |
Personal name | Heycock, Morgan W. D. |
Relator term | author |
9 (RLIN) | 1963 |
700 10 - ADDED ENTRY--PERSONAL NAME | |
Personal name | Shields, Jacqueline D. |
Relator term | author |
9 (RLIN) | 2449 |
700 10 - ADDED ENTRY--PERSONAL NAME | |
Personal name | Barlow, Jillian L. |
Relator term | author |
9 (RLIN) | 2450 |
700 10 - ADDED ENTRY--PERSONAL NAME | |
Personal name | McKenzie, Andrew N. J. |
Relator term | author |
9 (RLIN) | 1968 |
786 0# - DATA SOURCE ENTRY | |
Note | Proc Natl Acad Sci U S A |
856 41 - ELECTRONIC LOCATION AND ACCESS | |
Uniform Resource Identifier | <a href="http://dx.doi.org/10.1073/pnas.2203454119">http://dx.doi.org/10.1073/pnas.2203454119</a> |
Public note | Connect to this object online. |
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