JOM KITA KE POLITEKNIK

Evoked Resonant Neural Activity in subthalamic local field potentials reflects basal ganglia network dynamics (Record no. 453)

MARC details
042 ## - AUTHENTICATION CODE
Authentication code dc
100 10 - MAIN ENTRY--PERSONAL NAME
Personal name Wiest, Christoph
Relator term author
9 (RLIN) 2669
245 00 - TITLE STATEMENT
Title Evoked Resonant Neural Activity in subthalamic local field potentials reflects basal ganglia network dynamics
260 ## - PUBLICATION, DISTRIBUTION, ETC.
Date of publication, distribution, etc. 2023-03.
500 ## - GENERAL NOTE
General note /pmc/articles/PMC7614125/
500 ## - GENERAL NOTE
General note /pubmed/36706929
520 ## - SUMMARY, ETC.
Summary, etc. Evoked resonant neural activity (ERNA) is induced by subthalamic deep brain stimulation (DBS) and was recently suggested as a marker of lead placement and contact selection in Parkinson's disease. Yet, its underlying mechanisms and how it is modulated by stimulation parameters are unclear. Here, we recorded local field potentials from 27 Parkinson's disease patients, while leads were externalised to scrutinise the ERNA. First, we show that ERNA in the time series waveform and spectrogram likely represent the same activity, which was contested before. Second, our results show that the ERNA has fast and slow dynamics during stimulation, consistent with the synaptic failure hypothesis. Third, we show that ERNA parameters are modulated by different DBS frequencies, intensities, medication states and stimulation modes (continuous DBS vs. adaptive DBS). These results suggest the ERNA might prove useful as a predictor of the best DBS frequency and lowest effective intensity in addition to contact selection. Changes with levodopa and DBS mode suggest that the ERNA may indicate the state of the cortico-basal ganglia circuit making it a putative biomarker to track clinical state in adaptive DBS.
540 ## - TERMS GOVERNING USE AND REPRODUCTION NOTE
Terms governing use and reproduction
540 ## - TERMS GOVERNING USE AND REPRODUCTION NOTE
Terms governing use and reproduction https://creativecommons.org/licenses/by/4.0/This work is licensed under a CC BY 4.0 (https://creativecommons.org/licenses/by/4.0/) International license.
546 ## - LANGUAGE NOTE
Language note en
690 ## - LOCAL SUBJECT ADDED ENTRY--TOPICAL TERM (OCLC, RLIN)
Topical term or geographic name as entry element Article
655 7# - INDEX TERM--GENRE/FORM
Genre/form data or focus term Text
Source of term local
700 10 - ADDED ENTRY--PERSONAL NAME
Personal name He, Shenghong
Relator term author
9 (RLIN) 2670
700 10 - ADDED ENTRY--PERSONAL NAME
Personal name Duchet, Benoit
Relator term author
9 (RLIN) 2671
700 10 - ADDED ENTRY--PERSONAL NAME
Personal name Pogosyan, Alek
Relator term author
9 (RLIN) 2672
700 10 - ADDED ENTRY--PERSONAL NAME
Personal name Benjaber, Moaad
Relator term author
9 (RLIN) 2673
700 10 - ADDED ENTRY--PERSONAL NAME
Personal name Denison, Timothy
Relator term author
9 (RLIN) 2674
700 10 - ADDED ENTRY--PERSONAL NAME
Personal name Hasegawa, Harutomo
Relator term author
9 (RLIN) 2675
700 10 - ADDED ENTRY--PERSONAL NAME
Personal name Ashkan, Keyoumars
Relator term author
9 (RLIN) 2676
700 10 - ADDED ENTRY--PERSONAL NAME
Personal name Baig, Fahd
Relator term author
9 (RLIN) 2677
700 10 - ADDED ENTRY--PERSONAL NAME
Personal name Bertaina, Ilaria
Relator term author
9 (RLIN) 2678
700 10 - ADDED ENTRY--PERSONAL NAME
Personal name Morgante, Francesca
Relator term author
9 (RLIN) 2679
700 10 - ADDED ENTRY--PERSONAL NAME
Personal name Pereira, Erlick A.
Relator term author
9 (RLIN) 2680
700 10 - ADDED ENTRY--PERSONAL NAME
Personal name Torrecillos, Flavie
Relator term author
9 (RLIN) 2681
700 10 - ADDED ENTRY--PERSONAL NAME
Personal name Tan, Huiling
Relator term author
9 (RLIN) 2682
786 0# - DATA SOURCE ENTRY
Note Neurobiol Dis
856 41 - ELECTRONIC LOCATION AND ACCESS
Uniform Resource Identifier <a href="http://dx.doi.org/10.1016/j.nbd.2023.106019">http://dx.doi.org/10.1016/j.nbd.2023.106019</a>
Public note Connect to this object online.

No items available.