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Refactored genetic codes enable bidirectional genetic isolation (Record no. 474)

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Personal name Zürcher, Jérôme F.
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9 (RLIN) 2826
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Title Refactored genetic codes enable bidirectional genetic isolation
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Date of publication, distribution, etc. 2022-11-04.
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General note /pmc/articles/PMC7614150/
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General note /pubmed/36264827
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Summary, etc. The near-universal genetic code defines the correspondence between codons in genes and amino acids in proteins. We refactored the structure of the genetic code in Escherichia coli and created orthogonal genetic codes that restrict the escape of synthetic genetic information into natural life. We developed orthogonal and mutually orthogonal horizontal gene transfer systems, which permit the transfer of genetic information between organisms that use the same genetic code but restrict the transfer of genetic information between organisms that use different genetic codes. Moreover, we showed that locking refactored codes into synthetic organisms completely blocks invasion by mobile genetic elements, which carry their own translation factors and successfully invade organisms with canonical and compressed genetic codes.
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Terms governing use and reproduction
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Language note en
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Topical term or geographic name as entry element Article
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Genre/form data or focus term Text
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Personal name Robertson, Wesley E.
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9 (RLIN) 2827
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Personal name Kappes, Tomás
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9 (RLIN) 2828
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Personal name Petris, Gianluca
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9 (RLIN) 2829
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Personal name Elliott, Thomas S.
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9 (RLIN) 2830
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Personal name Salmond, George P. C.
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9 (RLIN) 2831
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Personal name Chin, Jason W.
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9 (RLIN) 2832
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Note Science
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Uniform Resource Identifier <a href="http://dx.doi.org/10.1126/science.add8943">http://dx.doi.org/10.1126/science.add8943</a>
Public note Connect to this object online.

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