Cellular senescence is immunogenic and promotes anti-tumor immunity (Record no. 476)
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042 ## - AUTHENTICATION CODE | |
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Authentication code | dc |
100 10 - MAIN ENTRY--PERSONAL NAME | |
Personal name | Marin, Ines |
Relator term | author |
9 (RLIN) | 2841 |
245 00 - TITLE STATEMENT | |
Title | Cellular senescence is immunogenic and promotes anti-tumor immunity |
260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
Date of publication, distribution, etc. | 2022-10-27. |
500 ## - GENERAL NOTE | |
General note | /pmc/articles/PMC7614152/ |
500 ## - GENERAL NOTE | |
General note | /pubmed/36302218 |
520 ## - SUMMARY, ETC. | |
Summary, etc. | Cellular senescence is a stress response that activates innate immune cells, but little is known about its interplay with the adaptive immune system. Here, we show that senescent cells combine several features that render them highly efficient in activating dendritic cells (DCs) and antigen-specific CD8 T cells. This includes the release of alarmins, activation of interferon signaling, enhanced MHC class I machinery, and presentation of senescence-specific self-peptides that can activate CD8 T cells. In the context of cancer, immunization with senescent cancer cells elicits strong anti-tumor protection mediated by DCs and CD8 T cells. Interestingly, this protection is superior to immunization with cancer cells undergoing immunogenic cell death. Finally, the induction of senescence in human primary cancer cells also augments their ability to activate autologous antigen-specific tumor-infiltrating CD8 lymphocytes. Our study indicates that senescent cancer cells can be exploited to develop efficient and protective CD8-dependent anti-tumor immune responses. |
540 ## - TERMS GOVERNING USE AND REPRODUCTION NOTE | |
Terms governing use and reproduction | |
546 ## - LANGUAGE NOTE | |
Language note | en |
690 ## - LOCAL SUBJECT ADDED ENTRY--TOPICAL TERM (OCLC, RLIN) | |
Topical term or geographic name as entry element | Article |
655 7# - INDEX TERM--GENRE/FORM | |
Genre/form data or focus term | Text |
Source of term | local |
700 10 - ADDED ENTRY--PERSONAL NAME | |
Personal name | Boix, Olga |
Relator term | author |
9 (RLIN) | 2842 |
700 10 - ADDED ENTRY--PERSONAL NAME | |
Personal name | Garcia-Garijo, Andrea |
Relator term | author |
9 (RLIN) | 2843 |
700 10 - ADDED ENTRY--PERSONAL NAME | |
Personal name | Sirois, Isabelle |
Relator term | author |
9 (RLIN) | 2844 |
700 10 - ADDED ENTRY--PERSONAL NAME | |
Personal name | Caballe, Adrià |
Relator term | author |
9 (RLIN) | 2845 |
700 10 - ADDED ENTRY--PERSONAL NAME | |
Personal name | Zarzuela, Eduardo |
Relator term | author |
9 (RLIN) | 2846 |
700 10 - ADDED ENTRY--PERSONAL NAME | |
Personal name | Ruano, Irene |
Relator term | author |
9 (RLIN) | 2847 |
700 10 - ADDED ENTRY--PERSONAL NAME | |
Personal name | Attolini, Camille Stephan-Otto |
Relator term | author |
9 (RLIN) | 2848 |
700 10 - ADDED ENTRY--PERSONAL NAME | |
Personal name | Prats, Neus |
Relator term | author |
9 (RLIN) | 2849 |
700 10 - ADDED ENTRY--PERSONAL NAME | |
Personal name | López-Domínguez, José A |
Relator term | author |
9 (RLIN) | 2850 |
700 10 - ADDED ENTRY--PERSONAL NAME | |
Personal name | Kovatcheva, Marta |
Relator term | author |
9 (RLIN) | 2851 |
700 10 - ADDED ENTRY--PERSONAL NAME | |
Personal name | Garralda, Elena |
Relator term | author |
9 (RLIN) | 2852 |
700 10 - ADDED ENTRY--PERSONAL NAME | |
Personal name | Muñoz, Javier |
Relator term | author |
9 (RLIN) | 2853 |
700 10 - ADDED ENTRY--PERSONAL NAME | |
Personal name | Caron, Etienne |
Relator term | author |
9 (RLIN) | 2854 |
700 10 - ADDED ENTRY--PERSONAL NAME | |
Personal name | Abad, María |
Relator term | author |
9 (RLIN) | 2855 |
700 10 - ADDED ENTRY--PERSONAL NAME | |
Personal name | Gros, Alena |
Relator term | author |
9 (RLIN) | 2856 |
700 10 - ADDED ENTRY--PERSONAL NAME | |
Personal name | Pietrocola, Federico |
Relator term | author |
9 (RLIN) | 2857 |
700 10 - ADDED ENTRY--PERSONAL NAME | |
Personal name | Serrano, Manuel |
Relator term | author |
9 (RLIN) | 2858 |
786 0# - DATA SOURCE ENTRY | |
Note | Cancer Discov |
856 41 - ELECTRONIC LOCATION AND ACCESS | |
Uniform Resource Identifier | <a href="http://dx.doi.org/10.1158/2159-8290.CD-22-0523">http://dx.doi.org/10.1158/2159-8290.CD-22-0523</a> |
Public note | Connect to this object online. |
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