JOM KITA KE POLITEKNIK

Input-dependent segregation of visual and somatosensory circuits in the mouse superior colliculus (Record no. 481)

MARC details
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Personal name Guillamón-Vivancos, Teresa
Relator term author
9 (RLIN) 2890
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Title Input-dependent segregation of visual and somatosensory circuits in the mouse superior colliculus
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Date of publication, distribution, etc. 2022-08-19.
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General note /pmc/articles/PMC7614159/
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General note /pubmed/35981041
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Summary, etc. Whereas sensory perception relies on specialized sensory pathways, it is unclear whether these pathways originate as modality-specific circuits. We demonstrated that somatosensory and visual circuits are not by default segregated but require the earliest retinal activity to do so. In the embryo, somatosensory and visual circuits are intermingled in the superior colliculus, leading to cortical multimodal responses to whisker pad stimulation. At birth, these circuits segregate, and responses switch to unimodal. Blocking stage I retinal waves prolongs the multimodal configuration into postnatal life, with the superior colliculus retaining a mixed somato-visual molecular identity and defects arising in the spatial organization of the visual system. Hence, the superior colliculus mediates the timely segregation of sensory modalities in an input-dependent manner, channeling specific sensory cues to their appropriate sensory pathway.
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Terms governing use and reproduction
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Terms governing use and reproduction https://www.science.org/about/science-licenses-journal-article-reuseexclusive licensee American Association for the Advancement of Science. No claim to original US government works. https://www.science.org/about/science-licenses-journal-article-reuse
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Language note en
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Topical term or geographic name as entry element Article
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Genre/form data or focus term Text
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Personal name Aníbal-Martínez, Mar
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9 (RLIN) 2891
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Personal name Puche-Aroca, Lorenzo
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9 (RLIN) 2892
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Personal name Moreno-Bravo, Juan Antonio
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9 (RLIN) 2893
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Personal name Valdeolmillos, Miguel
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9 (RLIN) 2894
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Personal name Martini, Francisco J.
Relator term author
9 (RLIN) 2895
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Personal name López-Bendito, Guillermina
Relator term author
9 (RLIN) 2896
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Note Science
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Uniform Resource Identifier <a href="http://dx.doi.org/10.1126/science.abq2960">http://dx.doi.org/10.1126/science.abq2960</a>
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