JOM KITA KE POLITEKNIK

The gut microbiome and child mental health: A population-based study (Record no. 483)

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Personal name Kraaij, Robert
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9 (RLIN) 2907
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Title The gut microbiome and child mental health: A population-based study
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Date of publication, distribution, etc. 2023-02-01.
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General note /pmc/articles/PMC7614161/
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General note /pubmed/36494050
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Summary, etc. The link between the gut microbiome and the brain has gained increasing scientific and public interest for its potential to explain psychiatric risk. While differences in gut microbiome composition have been associated with several mental health problems, evidence to date has been largely based on animal models and human studies with modest sample sizes. In this cross-sectional study in 1,784 ten-year-old children from the multi-ethnic, population-based Generation R Study, we aimed to characterize associations of the gut microbiome with child mental health problems. Gut microbiome was assessed from stool samples using 16S rRNA sequencing. We focused on overall psychiatric symptoms as well as with specific domains of emotional and behavioral problems, assessed via the maternally rated Child Behavior Checklist. While we observed lower gut microbiome diversity in relation to higher overall and specific mental health problems, associations were not significant. Likewise, we did not identify any taxonomic feature associated with mental health problems after multiple testing correction, although suggestive findings indicated depletion of genera previously associated with psychiatric disorders, including Hungatella, Anaerotruncus and Oscillospiraceae. The identified compositional abundance differences were found to be similar across all mental health problems. Finally, we did not find significant enrichment for specific microbial functions in relation to mental health problems. In conclusion, based on the largest sample examined to date, we do not find clear evidence of associations between gut microbiome diversity, taxonomies or functions and mental health problems in the general pediatric population. In future, the use of longitudinal designs with repeated measurements of microbiome and psychiatric outcomes will be critical to identify whether and when associations between the gut microbiome and mental health emerge across development and into adulthood.
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Terms governing use and reproduction
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Terms governing use and reproduction https://creativecommons.org/licenses/by/4.0/This work is licensed under a CC BY 4.0 (https://creativecommons.org/licenses/by/4.0/) International license.
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Language note en
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Topical term or geographic name as entry element Article
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Personal name Schuurmans, Isabel K.
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9 (RLIN) 2908
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Personal name Radjabzadeh, Djawad
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9 (RLIN) 2909
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Personal name Tiemeier, Henning
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9 (RLIN) 2910
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Personal name Dinan, Timothy G.
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9 (RLIN) 2911
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Personal name Uitterlinden, André G.
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9 (RLIN) 2912
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Personal name Hillegers, Manon
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9 (RLIN) 2913
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Personal name Jaddoe, Vincent W.V.
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9 (RLIN) 2914
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Personal name Duijts, Liesbeth
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9 (RLIN) 2915
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Personal name Moll, Henriette
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9 (RLIN) 2916
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Personal name Rivadeneira, Fernando
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9 (RLIN) 2917
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Personal name Medina-Gomez, Carolina
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9 (RLIN) 2918
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Personal name Jansen, Pauline W.
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9 (RLIN) 2919
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Personal name Cecil, Charlotte A.M.
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9 (RLIN) 2920
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Note Brain Behav Immun
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Uniform Resource Identifier <a href="http://dx.doi.org/10.1016/j.bbi.2022.12.006">http://dx.doi.org/10.1016/j.bbi.2022.12.006</a>
Public note Connect to this object online.

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