JOM KITA KE POLITEKNIK

Mapping gene by early life stress interactions on child subcortical brain structures: A genome-wide prospective study (Record no. 485)

MARC details
042 ## - AUTHENTICATION CODE
Authentication code dc
100 10 - MAIN ENTRY--PERSONAL NAME
Personal name Bolhuis, Koen
Relator term author
9 (RLIN) 2940
245 00 - TITLE STATEMENT
Title Mapping gene by early life stress interactions on child subcortical brain structures: A genome-wide prospective study
260 ## - PUBLICATION, DISTRIBUTION, ETC.
Date of publication, distribution, etc. 2022-11-16.
500 ## - GENERAL NOTE
General note /pmc/articles/PMC7614163/
500 ## - GENERAL NOTE
General note /pubmed/36777645
520 ## - SUMMARY, ETC.
Summary, etc. BACKGROUND: Although it is well-established that both genetics and the environment influence brain development, they are typically examined separately. Here, we aimed to prospectively investigate the interactive effects of genetic variants-from a genome-wide approach-and early life stress (ELS) on child subcortical brain structures, and their association with subsequent mental health problems. METHOD: Primary analyses were conducted using data from the Generation R Study (N = 2257), including genotype and cumulative prenatal and postnatal ELS scores (encompassing life events, contextual risk, parental risk, interpersonal risk, direct victimisation). Neuroimaging data were collected at age 10 years, including intracranial and subcortical brain volumes (accumbens, amygdala, caudate, hippocampus, pallidum, putamen, thalamus). Genome-wide association and genome-wide-by-environment interaction analyses (GWEIS, run separately for prenatal/postnatal ELS) were conducted for eight brain outcomes (i.e., 24 genome-wide analyses) in the Generation R Study (discovery). Polygenic scores (PGS) using the resulting weights were calculated in an independent (target) cohort (adolescent brain cognitive development Study; N = 10,751), to validate associations with corresponding subcortical volumes and examine links to later mother-reported internalising and externalising problems. RESULTS: One GWEIS-prenatal stress locus was associated with caudate volume (rs139505895, mapping onto PRSS12 and NDST3) and two GWEIS-postnatal stress loci with the accumbens (rs2397823 and rs3130008, mapping onto CUTA, SYNGAP1, and TABP). Functional annotation revealed that these genes play a role in neuronal plasticity and synaptic function, and have been implicated in neuro-developmental phenotypes, for example, intellectual disability, autism, and schizophrenia. None of these associations survived a more stringent correction for multiple testing across all analysis sets. In the validation sample, all PGS(genotype) were associated with their respective brain volumes, but no PGS(GxE) associated with any subcortical volume. None of the PGS associated with internalising or externalising problems. CONCLUSIONS: This study lends novel suggestive insights into gene-environment interplay on the developing brain as well as pointing to promising candidate loci for future replication and mechanistic studies.
540 ## - TERMS GOVERNING USE AND REPRODUCTION NOTE
Terms governing use and reproduction
540 ## - TERMS GOVERNING USE AND REPRODUCTION NOTE
Terms governing use and reproduction https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited https://creativecommons.org/licenses/by/4.0/.
540 ## - TERMS GOVERNING USE AND REPRODUCTION NOTE
Terms governing use and reproduction https://creativecommons.org/licenses/by/4.0/This work is licensed under a CC BY 4.0 (https://creativecommons.org/licenses/by/4.0/) International license.
546 ## - LANGUAGE NOTE
Language note en
690 ## - LOCAL SUBJECT ADDED ENTRY--TOPICAL TERM (OCLC, RLIN)
Topical term or geographic name as entry element Article
655 7# - INDEX TERM--GENRE/FORM
Genre/form data or focus term Text
Source of term local
700 10 - ADDED ENTRY--PERSONAL NAME
Personal name Mulder, Rosa H.
Relator term author
9 (RLIN) 2941
700 10 - ADDED ENTRY--PERSONAL NAME
Personal name de Mol, Casper Louk
Relator term author
9 (RLIN) 2942
700 10 - ADDED ENTRY--PERSONAL NAME
Personal name Defina, Serena
Relator term author
9 (RLIN) 2943
700 10 - ADDED ENTRY--PERSONAL NAME
Personal name Warrier, Varun
Relator term author
9 (RLIN) 2944
700 10 - ADDED ENTRY--PERSONAL NAME
Personal name White, Tonya
Relator term author
9 (RLIN) 2945
700 10 - ADDED ENTRY--PERSONAL NAME
Personal name Tiemeier, Henning
Relator term author
9 (RLIN) 2946
700 10 - ADDED ENTRY--PERSONAL NAME
Personal name Muetzel, Ryan L.
Relator term author
9 (RLIN) 2947
700 10 - ADDED ENTRY--PERSONAL NAME
Personal name Cecil, Charlotte A. M.
Relator term author
9 (RLIN) 2948
786 0# - DATA SOURCE ENTRY
Note JCPP Adv
856 41 - ELECTRONIC LOCATION AND ACCESS
Uniform Resource Identifier <a href="http://dx.doi.org/10.1002/jcv2.12113">http://dx.doi.org/10.1002/jcv2.12113</a>
Public note Connect to this object online.

No items available.