Fibroblast Growth Factor-23 and Risk of Cardiovascular Diseases: a Mendelian Randomization study (Record no. 512)
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042 ## - AUTHENTICATION CODE | |
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Authentication code | dc |
100 10 - MAIN ENTRY--PERSONAL NAME | |
Personal name | Donovan, Killian |
Relator term | author |
9 (RLIN) | 3106 |
245 00 - TITLE STATEMENT | |
Title | Fibroblast Growth Factor-23 and Risk of Cardiovascular Diseases: a Mendelian Randomization study |
260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
Date of publication, distribution, etc. | 2023-01-01. |
500 ## - GENERAL NOTE | |
General note | /pmc/articles/PMC7614195/ |
500 ## - GENERAL NOTE | |
General note | /pubmed/36719157 |
520 ## - SUMMARY, ETC. | |
Summary, etc. | BACKGROUND: Fibroblast growth factor 23 (FGF-23) is associated with a range of cardiovascular and non-cardiovascular diseases in conventional epidemiological studies, but substantial residual confounding may exist. Mendelian randomization approaches can help control for such confounding. METHODS: SCALLOP consortium data on 19,195 participants were used to generate an FGF-23 genetic score. Data from 337,448 UK Biobank participants were used to estimate associations between higher genetically-predicted FGF-23 concentration and the odds of any atherosclerotic cardiovascular disease (n=26,266 events), of any non-atherosclerotic cardiovascular disease (n=12,652), and of non-cardiovascular diseases previously linked to FGF-23. Measurements of carotid intima-media thickness and left ventricular mass were available in a subset. Associations with cardiovascular outcomes were also tested in three large case-control consortia: CARDIOGRAMplusC4D (coronary artery disease, n=181,249 cases), MEGASTROKE (stroke, n=34,217), and HERMES (heart failure, n=47,309). RESULTS: We identified 34 independent variants for circulating FGF-23 which formed a validated genetic score. There were no associations between genetically-predicted FGF-23 and any of the cardiovascular or non-cardiovascular outcomes. In UK Biobank, the odds ratio for any atherosclerotic cardiovascular disease per 1-SD higher genetically-predicted logFGF-23 was 1.03 (95% confidence interval [CI] 0.98-1.08), and for any non-atherosclerotic cardiovascular disease was 1.01 (0.94-1.09). The odds ratios in the case-control consortia were 1.00 (0.97-1.03) for coronary artery disease, 1.01 (0.95-1.07) for stroke, and 1.00 (0.95-1.05) for heart failure. In those with imaging, logFGF-23 was not associated with carotid or cardiac abnormalties. CONCLUSION: Genetically predicted FGF-23 levels are not associated atherosclerotic and non-atherosclerotic cardiovascular diseases, suggesting no important causal link. |
540 ## - TERMS GOVERNING USE AND REPRODUCTION NOTE | |
Terms governing use and reproduction | |
540 ## - TERMS GOVERNING USE AND REPRODUCTION NOTE | |
Terms governing use and reproduction | https://creativecommons.org/licenses/by/4.0/Open Access For the purpose of open access, the author(s) has applied a Creative Commons Attribution (CC BY) licence to any Author Accepted Manuscript version arising. (https://creativecommons.org/licenses/by/4.0/) |
546 ## - LANGUAGE NOTE | |
Language note | en |
690 ## - LOCAL SUBJECT ADDED ENTRY--TOPICAL TERM (OCLC, RLIN) | |
Topical term or geographic name as entry element | Article |
655 7# - INDEX TERM--GENRE/FORM | |
Genre/form data or focus term | Text |
Source of term | local |
700 10 - ADDED ENTRY--PERSONAL NAME | |
Personal name | Herrington, William G. |
Relator term | author |
9 (RLIN) | 2196 |
700 10 - ADDED ENTRY--PERSONAL NAME | |
Personal name | Paré, Guillaume |
Relator term | author |
9 (RLIN) | 3107 |
700 10 - ADDED ENTRY--PERSONAL NAME | |
Personal name | Pigeyre, Marie |
Relator term | author |
9 (RLIN) | 3108 |
700 10 - ADDED ENTRY--PERSONAL NAME | |
Personal name | Haynes, Richard |
Relator term | author |
9 (RLIN) | 2234 |
700 10 - ADDED ENTRY--PERSONAL NAME | |
Personal name | Sardell, Rebecca |
Relator term | author |
9 (RLIN) | 3109 |
700 10 - ADDED ENTRY--PERSONAL NAME | |
Personal name | Butterworth, Adam S. |
Relator term | author |
9 (RLIN) | 3110 |
700 10 - ADDED ENTRY--PERSONAL NAME | |
Personal name | Folkersen, Lasse |
Relator term | author |
9 (RLIN) | 3111 |
700 10 - ADDED ENTRY--PERSONAL NAME | |
Personal name | Gustafsson, Stefan |
Relator term | author |
9 (RLIN) | 3112 |
700 10 - ADDED ENTRY--PERSONAL NAME | |
Personal name | Wang, Qin |
Relator term | author |
9 (RLIN) | 3113 |
700 10 - ADDED ENTRY--PERSONAL NAME | |
Personal name | Baigent, Colin |
Relator term | author |
9 (RLIN) | 2233 |
700 10 - ADDED ENTRY--PERSONAL NAME | |
Personal name | Mälarstig, Anders |
Relator term | author |
9 (RLIN) | 3114 |
700 10 - ADDED ENTRY--PERSONAL NAME | |
Personal name | Holmes, Michael V. |
Relator term | author |
9 (RLIN) | 3115 |
700 10 - ADDED ENTRY--PERSONAL NAME | |
Personal name | Staplin, Natalie |
Relator term | author |
9 (RLIN) | 2197 |
786 0# - DATA SOURCE ENTRY | |
Note | Clin J Am Soc Nephrol |
856 41 - ELECTRONIC LOCATION AND ACCESS | |
Uniform Resource Identifier | <a href="http://dx.doi.org/10.2215/CJN.05080422">http://dx.doi.org/10.2215/CJN.05080422</a> |
Public note | Connect to this object online. |
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