JOM KITA KE POLITEKNIK

Mesp1 controls the chromatin and enhancer landscapes essential for spatiotemporal patterning of early cardiovascular progenitors (Record no. 775)

MARC details
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Personal name Lin, Xionghui
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9 (RLIN) 1154
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Title Mesp1 controls the chromatin and enhancer landscapes essential for spatiotemporal patterning of early cardiovascular progenitors
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Date of publication, distribution, etc. 2022-07-01.
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General note /pmc/articles/PMC7613098/
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General note /pubmed/35817961
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Summary, etc. The mammalian heart arises from various populations of Mesp1-expressing cardiovascular progenitors (CPs) that are specified during the early stages of gastrulation. Mesp1 is a transcription factor (TF) that acts as a master regulator of CP specification and differentiation. However, how Mesp1 regulates the chromatin landscape of nascent mesodermal cells to define the temporal and spatial patterning of the distinct populations of CPs remains unknown. Here, by combining ChIP-seq, RNA-seq and ATAC-seq during mouse pluripotent stem cell differentiation, we defined the dynamic remodelling of the chromatin landscape mediated by Mesp1. We identified different enhancers that are temporally regulated to erase the pluripotent state and specify the pools of CPs that mediate heart development. We identified Zic2 and Zic3 as essential cofactors that act with Mesp1 to regulate its TF activity at key mesodermal enhancers, thereby regulating the chromatin remodelling and gene expression associated with the specification of the different populations of CPs in vivo. Our study identifies the dynamics of the chromatin landscape and enhancer remodelling associated with temporal patterning of early mesodermal cells into the distinct populations of CPs that mediate heart development.
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Terms governing use and reproduction
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Terms governing use and reproduction https://www.springernature.com/gp/open-research/policies/accepted-manuscript-termsUsers may view, print, copy, and download text and data-mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use: https://www.springernature.com/gp/open-research/policies/accepted-manuscript-terms.
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Language note en
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Topical term or geographic name as entry element Article
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Genre/form data or focus term Text
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Personal name Swedlund, Benjamin
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9 (RLIN) 1155
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Personal name Ton, Mai-Linh N.
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9 (RLIN) 1156
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Personal name Ghazanfar, Shila
Relator term author
9 (RLIN) 1157
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Personal name Guibentif, Carolina
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9 (RLIN) 1158
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Personal name Paulissen, Catherine
Relator term author
9 (RLIN) 1159
700 10 - ADDED ENTRY--PERSONAL NAME
Personal name Baudelet, Elodie
Relator term author
9 (RLIN) 1160
700 10 - ADDED ENTRY--PERSONAL NAME
Personal name Plaindoux, Elise
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9 (RLIN) 1161
700 10 - ADDED ENTRY--PERSONAL NAME
Personal name Achouri, Younes
Relator term author
9 (RLIN) 1162
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Personal name Calonne, Emilie
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9 (RLIN) 1163
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Personal name Dubois, Christine
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9 (RLIN) 1164
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Personal name Mansfield, William
Relator term author
9 (RLIN) 1165
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Personal name Zaffran, Stéphane
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9 (RLIN) 1166
700 10 - ADDED ENTRY--PERSONAL NAME
Personal name Marioni, John C.
Relator term author
9 (RLIN) 1167
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Personal name Fuks, Francois
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9 (RLIN) 1168
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Personal name Göttgens, Berthold
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9 (RLIN) 1169
700 10 - ADDED ENTRY--PERSONAL NAME
Personal name Lescroart, Fabienne
Relator term author
9 (RLIN) 1170
700 10 - ADDED ENTRY--PERSONAL NAME
Personal name Blanpain, Cédric
Relator term author
9 (RLIN) 1171
786 0# - DATA SOURCE ENTRY
Note Nat Cell Biol
856 41 - ELECTRONIC LOCATION AND ACCESS
Uniform Resource Identifier <a href="http://dx.doi.org/10.1038/s41556-022-00947-3">http://dx.doi.org/10.1038/s41556-022-00947-3</a>
Public note Connect to this object online.

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