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Evolution of isoform-level gene expression patterns across tissues during lotus species divergence (Record no. 807)

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100 10 - MAIN ENTRY--PERSONAL NAME
Personal name Zhang, Yue
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9 (RLIN) 1437
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Title Evolution of isoform-level gene expression patterns across tissues during lotus species divergence
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Date of publication, distribution, etc. 2022-09-19.
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General note /pmc/articles/PMC7613771/
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General note /pubmed/36123806
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Summary, etc. Both gene duplication and alternative splicing (AS) drive the functional diversity of gene products in plants, yet the relative contribution of the two key mechanisms to the evolution of gene function is largely unclear. Here, we studied AS in two closely related lotus plants, Nelumbo lutea, N. nucifera, and the outgroup Arabidopsis thaliana, for both single-copy and duplicated genes. We show that most splicing events evolved rapidly between orthologs, and that the origin of lineage-specific splice variants or isoforms contributed to gene functional changes during species divergence within Nelumbo. Single-copy genes contain more isoforms, have more AS events conserved across species, and show more complex tissue-dependent expression patterns than their duplicated counterparts. This suggests that expression divergence through isoforms is a mechanism to extend the expression breadth of genes with low copy numbers. As compared to isoforms from local, small-scale duplicated, isoforms of whole-genome duplicates are less conserved and display a less conserved tissue bias, pointing towards their contribution to subfunctionalization. Through comparative analysis of isoform expression networks, we identified orthologous genes of which the expression of at least some of their isoforms displays a conserved tissue bias across species, indicating a strong selection for maintaining a stable expression pattern of these isoforms. Overall, our study shows that both AS and gene duplication contribute to creating the diversity of gene function during the evolution of lotus.
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Language note en
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Topical term or geographic name as entry element Article
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Genre/form data or focus term Text
Source of term local
700 10 - ADDED ENTRY--PERSONAL NAME
Personal name Yang, Xingyu
Relator term author
9 (RLIN) 1438
700 10 - ADDED ENTRY--PERSONAL NAME
Personal name Van de Peer, Yves
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700 10 - ADDED ENTRY--PERSONAL NAME
Personal name Chen, Jinming
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9 (RLIN) 1440
700 10 - ADDED ENTRY--PERSONAL NAME
Personal name Marchal, Kathleen
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9 (RLIN) 1441
700 10 - ADDED ENTRY--PERSONAL NAME
Personal name Shi, Tao
Relator term author
9 (RLIN) 1442
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Note Plant J
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Uniform Resource Identifier <a href="http://dx.doi.org/10.1111/tpj.15984">http://dx.doi.org/10.1111/tpj.15984</a>
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