Adult human kidney organoids originate from CD24(+) cells and represent an advanced model for adult polycystic kidney disease (Record no. 816)
[ view plain ]
042 ## - AUTHENTICATION CODE | |
---|---|
Authentication code | dc |
100 10 - MAIN ENTRY--PERSONAL NAME | |
Personal name | Xu, Yaoxian |
Relator term | author |
9 (RLIN) | 1567 |
245 00 - TITLE STATEMENT | |
Title | Adult human kidney organoids originate from CD24(+) cells and represent an advanced model for adult polycystic kidney disease |
260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
Date of publication, distribution, etc. | 2022-11. |
500 ## - GENERAL NOTE | |
General note | /pmc/articles/PMC7613830/ |
500 ## - GENERAL NOTE | |
General note | /pubmed/36303074 |
520 ## - SUMMARY, ETC. | |
Summary, etc. | Adult kidney organoids have been described as strictly tubular epithelial and termed tubuloids. While the cellular origin of tubuloids has remained elusive, here we report that they originate from a distinct CD24(+) epithelial subpopulation. Long-term-cultured CD24(+)-derived tubuloids represent a functional human kidney tubule. We show that kidney tubuloids can be used to model the most common inherited kidney disease, namely autosomal dominant polycystic kidney disease (ADPKD), reconstituting the phenotypic hallmark of this disease with cyst formation. Single-cell RNA sequencing of CRISPR/Cas9 gene-edited PKD1 and PKD2 knockout tubuloids and human ADPKD and control tissue show similarities in upregulation of disease-driving genes. Furthermore, in a proof of concept, we demonstrate that tolvaptan, the only approved drug for ADPKD, shows a significant effect on cyst size in tubuloids but no effect in a pluripotent-stem-cell-derived model. Thus, tubuloids derive from a tubular epithelial subpopulation and represent an advanced model for ADPKD disease modeling. |
540 ## - TERMS GOVERNING USE AND REPRODUCTION NOTE | |
Terms governing use and reproduction | |
540 ## - TERMS GOVERNING USE AND REPRODUCTION NOTE | |
Terms governing use and reproduction | https://www.springernature.com/gp/open-research/policies/accepted-manuscript-termsUsers may view, print, copy, and download text and data-mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use: https://www.springernature.com/gp/open-research/policies/accepted-manuscript-terms |
546 ## - LANGUAGE NOTE | |
Language note | en |
690 ## - LOCAL SUBJECT ADDED ENTRY--TOPICAL TERM (OCLC, RLIN) | |
Topical term or geographic name as entry element | Article |
655 7# - INDEX TERM--GENRE/FORM | |
Genre/form data or focus term | Text |
Source of term | local |
700 10 - ADDED ENTRY--PERSONAL NAME | |
Personal name | Kuppe, Christoph |
Relator term | author |
9 (RLIN) | 1568 |
700 10 - ADDED ENTRY--PERSONAL NAME | |
Personal name | Perales-Patón, Javier |
Relator term | author |
9 (RLIN) | 1569 |
700 10 - ADDED ENTRY--PERSONAL NAME | |
Personal name | Hayat, Sikander |
Relator term | author |
9 (RLIN) | 1570 |
700 10 - ADDED ENTRY--PERSONAL NAME | |
Personal name | Kranz, Jennifer |
Relator term | author |
9 (RLIN) | 1571 |
700 10 - ADDED ENTRY--PERSONAL NAME | |
Personal name | Abdallah, Ali T. |
Relator term | author |
9 (RLIN) | 1572 |
700 10 - ADDED ENTRY--PERSONAL NAME | |
Personal name | Nagai, James |
Relator term | author |
9 (RLIN) | 1573 |
700 10 - ADDED ENTRY--PERSONAL NAME | |
Personal name | Li, Zhijian |
Relator term | author |
9 (RLIN) | 1574 |
700 10 - ADDED ENTRY--PERSONAL NAME | |
Personal name | Peisker, Fabian |
Relator term | author |
9 (RLIN) | 1575 |
700 10 - ADDED ENTRY--PERSONAL NAME | |
Personal name | Saritas, Turgay |
Relator term | author |
9 (RLIN) | 1576 |
700 10 - ADDED ENTRY--PERSONAL NAME | |
Personal name | Halder, Maurice |
Relator term | author |
9 (RLIN) | 1577 |
700 10 - ADDED ENTRY--PERSONAL NAME | |
Personal name | Menzel, Sylvia |
Relator term | author |
9 (RLIN) | 1578 |
700 10 - ADDED ENTRY--PERSONAL NAME | |
Personal name | Hoeft, Konrad |
Relator term | author |
9 (RLIN) | 1579 |
700 10 - ADDED ENTRY--PERSONAL NAME | |
Personal name | Kenter, Annegien |
Relator term | author |
9 (RLIN) | 1580 |
700 10 - ADDED ENTRY--PERSONAL NAME | |
Personal name | Kim, Hyojin |
Relator term | author |
9 (RLIN) | 1581 |
700 10 - ADDED ENTRY--PERSONAL NAME | |
Personal name | van Roeyen, Claudia R. C. |
Relator term | author |
9 (RLIN) | 1582 |
700 10 - ADDED ENTRY--PERSONAL NAME | |
Personal name | Lehrke, Michael |
Relator term | author |
9 (RLIN) | 1583 |
700 10 - ADDED ENTRY--PERSONAL NAME | |
Personal name | Moellmann, Julia |
Relator term | author |
9 (RLIN) | 1584 |
700 10 - ADDED ENTRY--PERSONAL NAME | |
Personal name | Speer, Thimoteus |
Relator term | author |
9 (RLIN) | 1585 |
700 10 - ADDED ENTRY--PERSONAL NAME | |
Personal name | Buhl, Eva M. |
Relator term | author |
9 (RLIN) | 1586 |
700 10 - ADDED ENTRY--PERSONAL NAME | |
Personal name | Hoogenboezem, Remco |
Relator term | author |
9 (RLIN) | 1587 |
700 10 - ADDED ENTRY--PERSONAL NAME | |
Personal name | Boor, Peter |
Relator term | author |
9 (RLIN) | 1588 |
700 10 - ADDED ENTRY--PERSONAL NAME | |
Personal name | Jansen, Jitske |
Relator term | author |
9 (RLIN) | 1589 |
700 10 - ADDED ENTRY--PERSONAL NAME | |
Personal name | Knopp, Cordula |
Relator term | author |
9 (RLIN) | 1590 |
700 10 - ADDED ENTRY--PERSONAL NAME | |
Personal name | Kurth, Ingo |
Relator term | author |
9 (RLIN) | 1591 |
700 10 - ADDED ENTRY--PERSONAL NAME | |
Personal name | Smeets, Bart |
Relator term | author |
9 (RLIN) | 1592 |
700 10 - ADDED ENTRY--PERSONAL NAME | |
Personal name | Bindels, Eric |
Relator term | author |
9 (RLIN) | 1593 |
700 10 - ADDED ENTRY--PERSONAL NAME | |
Personal name | Reinders, Marlies E. J. |
Relator term | author |
9 (RLIN) | 1594 |
700 10 - ADDED ENTRY--PERSONAL NAME | |
Personal name | Baan, Carla |
Relator term | author |
9 (RLIN) | 1595 |
700 10 - ADDED ENTRY--PERSONAL NAME | |
Personal name | Gribnau, Joost |
Relator term | author |
9 (RLIN) | 1596 |
700 10 - ADDED ENTRY--PERSONAL NAME | |
Personal name | Hoorn, Ewout J. |
Relator term | author |
9 (RLIN) | 1597 |
700 10 - ADDED ENTRY--PERSONAL NAME | |
Personal name | Steffens, Joachim |
Relator term | author |
9 (RLIN) | 1598 |
700 10 - ADDED ENTRY--PERSONAL NAME | |
Personal name | Huber, Tobias B |
Relator term | author |
9 (RLIN) | 1599 |
700 10 - ADDED ENTRY--PERSONAL NAME | |
Personal name | Costa, Ivan |
Relator term | author |
9 (RLIN) | 1600 |
700 10 - ADDED ENTRY--PERSONAL NAME | |
Personal name | Floege, Jürgen |
Relator term | author |
9 (RLIN) | 1601 |
700 10 - ADDED ENTRY--PERSONAL NAME | |
Personal name | Schneider, Rebekka K. |
Relator term | author |
9 (RLIN) | 1602 |
700 10 - ADDED ENTRY--PERSONAL NAME | |
Personal name | Saez-Rodriguez, Julio |
Relator term | author |
9 (RLIN) | 1603 |
700 10 - ADDED ENTRY--PERSONAL NAME | |
Personal name | Freedman, Benjamin S. |
Relator term | author |
9 (RLIN) | 1604 |
700 10 - ADDED ENTRY--PERSONAL NAME | |
Personal name | Kramann, Rafael |
Relator term | author |
9 (RLIN) | 1605 |
786 0# - DATA SOURCE ENTRY | |
Note | Nat Genet |
856 41 - ELECTRONIC LOCATION AND ACCESS | |
Uniform Resource Identifier | <a href="http://dx.doi.org/10.1038/s41588-022-01202-z">http://dx.doi.org/10.1038/s41588-022-01202-z</a> |
Public note | Connect to this object online. |
No items available.