JOM KITA KE POLITEKNIK

Adult human kidney organoids originate from CD24(+) cells and represent an advanced model for adult polycystic kidney disease (Record no. 816)

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100 10 - MAIN ENTRY--PERSONAL NAME
Personal name Xu, Yaoxian
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9 (RLIN) 1567
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Title Adult human kidney organoids originate from CD24(+) cells and represent an advanced model for adult polycystic kidney disease
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Date of publication, distribution, etc. 2022-11.
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General note /pmc/articles/PMC7613830/
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General note /pubmed/36303074
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Summary, etc. Adult kidney organoids have been described as strictly tubular epithelial and termed tubuloids. While the cellular origin of tubuloids has remained elusive, here we report that they originate from a distinct CD24(+) epithelial subpopulation. Long-term-cultured CD24(+)-derived tubuloids represent a functional human kidney tubule. We show that kidney tubuloids can be used to model the most common inherited kidney disease, namely autosomal dominant polycystic kidney disease (ADPKD), reconstituting the phenotypic hallmark of this disease with cyst formation. Single-cell RNA sequencing of CRISPR/Cas9 gene-edited PKD1 and PKD2 knockout tubuloids and human ADPKD and control tissue show similarities in upregulation of disease-driving genes. Furthermore, in a proof of concept, we demonstrate that tolvaptan, the only approved drug for ADPKD, shows a significant effect on cyst size in tubuloids but no effect in a pluripotent-stem-cell-derived model. Thus, tubuloids derive from a tubular epithelial subpopulation and represent an advanced model for ADPKD disease modeling.
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Terms governing use and reproduction
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Terms governing use and reproduction https://www.springernature.com/gp/open-research/policies/accepted-manuscript-termsUsers may view, print, copy, and download text and data-mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use: https://www.springernature.com/gp/open-research/policies/accepted-manuscript-terms
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Language note en
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Topical term or geographic name as entry element Article
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Genre/form data or focus term Text
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Personal name Kuppe, Christoph
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9 (RLIN) 1568
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Personal name Perales-Patón, Javier
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9 (RLIN) 1569
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Personal name Hayat, Sikander
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9 (RLIN) 1570
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Personal name Kranz, Jennifer
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Personal name Abdallah, Ali T.
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9 (RLIN) 1572
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Personal name Nagai, James
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9 (RLIN) 1573
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Personal name Li, Zhijian
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9 (RLIN) 1574
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Personal name Peisker, Fabian
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9 (RLIN) 1575
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Personal name Saritas, Turgay
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9 (RLIN) 1576
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Personal name Halder, Maurice
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9 (RLIN) 1577
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Personal name Menzel, Sylvia
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Personal name Hoeft, Konrad
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9 (RLIN) 1579
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Personal name Kenter, Annegien
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9 (RLIN) 1580
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Personal name Kim, Hyojin
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9 (RLIN) 1581
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Personal name van Roeyen, Claudia R. C.
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9 (RLIN) 1582
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Personal name Lehrke, Michael
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9 (RLIN) 1583
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Personal name Moellmann, Julia
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Personal name Speer, Thimoteus
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9 (RLIN) 1585
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Personal name Buhl, Eva M.
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9 (RLIN) 1586
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Personal name Hoogenboezem, Remco
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9 (RLIN) 1587
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Personal name Boor, Peter
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9 (RLIN) 1588
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Personal name Jansen, Jitske
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9 (RLIN) 1589
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Personal name Knopp, Cordula
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9 (RLIN) 1590
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Personal name Kurth, Ingo
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Personal name Smeets, Bart
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Personal name Bindels, Eric
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9 (RLIN) 1593
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Personal name Reinders, Marlies E. J.
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9 (RLIN) 1594
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Personal name Baan, Carla
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9 (RLIN) 1595
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Personal name Gribnau, Joost
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9 (RLIN) 1596
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Personal name Hoorn, Ewout J.
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9 (RLIN) 1597
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Personal name Steffens, Joachim
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9 (RLIN) 1598
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Personal name Huber, Tobias B
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9 (RLIN) 1599
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Personal name Costa, Ivan
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9 (RLIN) 1600
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Personal name Floege, Jürgen
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9 (RLIN) 1601
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Personal name Schneider, Rebekka K.
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9 (RLIN) 1602
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Personal name Saez-Rodriguez, Julio
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9 (RLIN) 1603
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Personal name Freedman, Benjamin S.
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9 (RLIN) 1604
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Personal name Kramann, Rafael
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9 (RLIN) 1605
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Note Nat Genet
856 41 - ELECTRONIC LOCATION AND ACCESS
Uniform Resource Identifier <a href="http://dx.doi.org/10.1038/s41588-022-01202-z">http://dx.doi.org/10.1038/s41588-022-01202-z</a>
Public note Connect to this object online.

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