An αvβ3 integrin checkpoint is critical for efficient T(H)2 cytokine polarisation and potentiating antigen-specific immunity (Record no. 859)
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042 ## - AUTHENTICATION CODE | |
---|---|
Authentication code | dc |
100 10 - MAIN ENTRY--PERSONAL NAME | |
Personal name | Szeto, Aydan C. H. |
Relator term | author |
9 (RLIN) | 1958 |
245 00 - TITLE STATEMENT | |
Title | An αvβ3 integrin checkpoint is critical for efficient T(H)2 cytokine polarisation and potentiating antigen-specific immunity |
260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
Date of publication, distribution, etc. | 2023-01. |
500 ## - GENERAL NOTE | |
General note | /pmc/articles/PMC7614022/ |
500 ## - GENERAL NOTE | |
General note | /pubmed/36550322 |
520 ## - SUMMARY, ETC. | |
Summary, etc. | Naïve CD4(+) T lymphocytes initially undergo antigen-specific activation to promote a broad-spectrum response before adopting bespoke cytokine expression profiles shaped by intercellular microenvironmental cues, resulting in pathogen-focussed modular cytokine responses. Interleukin (IL)-4-induced Gata3 upregulation is important for the T helper 2 (T(H)2) cell polarisation associated with anti-helminth immunity and misdirected allergic inflammation. Whether additional microenvironmental factors participate is unclear. Using whole mouse-genome CRISPR-Cas9 screens we discovered a previously unappreciated role for αvβ3 integrin in T(H)2 cell differentiation. Low-level αvβ3 expression by naïve CD4(+) T cells contributed to pan-T cell activation by promoting T-T cell clustering and IL-2/CD25/STAT5-signalling. Subsequently, IL-4/Gata3-induced selective upregulation of αvβ3 licenced intercellular αvβ3-Thy1 interactions among T(H)2 cells, enhanced mTOR signalling, supported differentiation and promoted IL-5/IL-13 production. In mice, αvβ3 was required for efficient allergen-driven antigen-specific lung T(H)2 cell responses. Thus, αvβ3-expressing T(H)2 cells form multicellular factories to propagate and amplify T(H)2 responses. |
540 ## - TERMS GOVERNING USE AND REPRODUCTION NOTE | |
Terms governing use and reproduction | |
540 ## - TERMS GOVERNING USE AND REPRODUCTION NOTE | |
Terms governing use and reproduction | https://creativecommons.org/licenses/by/4.0/This work is licensed under a CC BY 4.0 (https://creativecommons.org/licenses/by/4.0/) International license. |
546 ## - LANGUAGE NOTE | |
Language note | en |
690 ## - LOCAL SUBJECT ADDED ENTRY--TOPICAL TERM (OCLC, RLIN) | |
Topical term or geographic name as entry element | Article |
655 7# - INDEX TERM--GENRE/FORM | |
Genre/form data or focus term | Text |
Source of term | local |
700 10 - ADDED ENTRY--PERSONAL NAME | |
Personal name | Ferreira, Ana C. F. |
Relator term | author |
9 (RLIN) | 1959 |
700 10 - ADDED ENTRY--PERSONAL NAME | |
Personal name | Mannion, Jonathan |
Relator term | author |
9 (RLIN) | 1960 |
700 10 - ADDED ENTRY--PERSONAL NAME | |
Personal name | Clark, Paula A. |
Relator term | author |
9 (RLIN) | 1961 |
700 10 - ADDED ENTRY--PERSONAL NAME | |
Personal name | Sivasubramaniam, Meera |
Relator term | author |
9 (RLIN) | 1962 |
700 10 - ADDED ENTRY--PERSONAL NAME | |
Personal name | Heycock, Morgan W. D. |
Relator term | author |
9 (RLIN) | 1963 |
700 10 - ADDED ENTRY--PERSONAL NAME | |
Personal name | Crisp, Alastair |
Relator term | author |
9 (RLIN) | 1964 |
700 10 - ADDED ENTRY--PERSONAL NAME | |
Personal name | Jolin, Helen E. |
Relator term | author |
9 (RLIN) | 1965 |
700 10 - ADDED ENTRY--PERSONAL NAME | |
Personal name | Kozik, Patrycja |
Relator term | author |
9 (RLIN) | 1966 |
700 10 - ADDED ENTRY--PERSONAL NAME | |
Personal name | Knolle, Martin D. |
Relator term | author |
9 (RLIN) | 1967 |
700 10 - ADDED ENTRY--PERSONAL NAME | |
Personal name | McKenzie, Andrew N. J. |
Relator term | author |
9 (RLIN) | 1968 |
786 0# - DATA SOURCE ENTRY | |
Note | Nat Immunol |
856 41 - ELECTRONIC LOCATION AND ACCESS | |
Uniform Resource Identifier | <a href="http://dx.doi.org/10.1038/s41590-022-01378-w">http://dx.doi.org/10.1038/s41590-022-01378-w</a> |
Public note | Connect to this object online. |
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