JOM KITA KE POLITEKNIK

Empagliflozin in Patients with Chronic Kidney Disease (Record no. 887)

MARC details
042 ## - AUTHENTICATION CODE
Authentication code dc
245 00 - TITLE STATEMENT
Title Empagliflozin in Patients with Chronic Kidney Disease
260 ## - PUBLICATION, DISTRIBUTION, ETC.
Date of publication, distribution, etc. 2023-01-12.
500 ## - GENERAL NOTE
General note /pmc/articles/PMC7614055/
500 ## - GENERAL NOTE
General note /pubmed/36331190
520 ## - SUMMARY, ETC.
Summary, etc. BACKGROUND: This study, the EMPA-KIDNEY trial, was designed to assess the effects of empagliflozin in a broad range of patients with chronic kidney disease (CKD) at risk of progression. METHODS: We randomly assigned 6609 participants to empagliflozin (10mg once daily) versus matching placebo. Eligibility required an estimated glomerular filtration rate (eGFR) of ≥20 to <45 ml/minute/1.73m(2); or ≥45 to <90 ml/minute/1.73m(2) with a urinary albumin-to-creatinine ratio (ACR) of ≥200 mg/g. The primary outcome was a composite of kidney disease progression (end-stage kidney disease, a sustained eGFR <10 ml/minute/1.73m(2), a sustained decline in eGFR of ≥40%, or a renal death) or death from cardiovascular causes. RESULTS: During a median of 2.0 years follow-up, a primary outcome event occurred in 432 of 3304 patients (13.1%) in the empagliflozin group and in 558 of 3305 patients (16.9%) in the placebo group (hazard ratio, 0.72; 95% CI 0.64 to 0.82; P<0.001), with consistent results in those with or without diabetes and across the range of eGFR studied. There were fewer hospitalizations from any cause in the empagliflozin group (0.86; 0.78 to 0.95, P=0.003), but no statistically significant effect on hospitalization for heart failure or cardiovascular death (4.0% vs 4.6%), or death from any cause (4.5% vs 5.1%). The rates of serious adverse events were broadly similar in the two groups. CONCLUSIONS: Empagliflozin reduced the risk of the composite outcome of kidney disease progression or cardiovascular death in a wide range of patients at risk of CKD progression. (Funding:Boehringer Ingelheim, Eli Lilly and others; Clinicaltrials.gov:NCT03594110, EuDRACT: 2017-002971-24).
540 ## - TERMS GOVERNING USE AND REPRODUCTION NOTE
Terms governing use and reproduction
540 ## - TERMS GOVERNING USE AND REPRODUCTION NOTE
Terms governing use and reproduction https://creativecommons.org/licenses/by-nd/4.0/This work is licensed under a CC BY-ND 4.0 (https://creativecommons.org/licenses/by-nd/4.0/) International license.
546 ## - LANGUAGE NOTE
Language note en
690 ## - LOCAL SUBJECT ADDED ENTRY--TOPICAL TERM (OCLC, RLIN)
Topical term or geographic name as entry element Article
655 7# - INDEX TERM--GENRE/FORM
Genre/form data or focus term Text
Source of term local
700 10 - ADDED ENTRY--PERSONAL NAME
Personal name Herrington, William G.
Relator term author
9 (RLIN) 2196
700 10 - ADDED ENTRY--PERSONAL NAME
Personal name Staplin, Natalie
Relator term author
9 (RLIN) 2197
700 10 - ADDED ENTRY--PERSONAL NAME
Personal name Wanner, Christoph
Relator term author
9 (RLIN) 2198
700 10 - ADDED ENTRY--PERSONAL NAME
Personal name Green, Jennifer B.
Relator term author
9 (RLIN) 2199
700 10 - ADDED ENTRY--PERSONAL NAME
Personal name Hauske, Sibylle J.
Relator term author
9 (RLIN) 2200
700 10 - ADDED ENTRY--PERSONAL NAME
Personal name Emberson, Jonathan R.
Relator term author
9 (RLIN) 2201
700 10 - ADDED ENTRY--PERSONAL NAME
Personal name Preiss, David
Relator term author
9 (RLIN) 2202
700 10 - ADDED ENTRY--PERSONAL NAME
Personal name Judge, Parminder
Relator term author
9 (RLIN) 2203
700 10 - ADDED ENTRY--PERSONAL NAME
Personal name Mayne, Kaitlin J.
Relator term author
9 (RLIN) 2204
700 10 - ADDED ENTRY--PERSONAL NAME
Personal name Ng, Sarah Y.A.
Relator term author
9 (RLIN) 2205
700 10 - ADDED ENTRY--PERSONAL NAME
Personal name Sammons, Emily
Relator term author
9 (RLIN) 2206
700 10 - ADDED ENTRY--PERSONAL NAME
Personal name Zhu, Doreen
Relator term author
9 (RLIN) 2207
700 10 - ADDED ENTRY--PERSONAL NAME
Personal name Hill, Michael
Relator term author
9 (RLIN) 2208
700 10 - ADDED ENTRY--PERSONAL NAME
Personal name Stevens, Will
Relator term author
9 (RLIN) 2209
700 10 - ADDED ENTRY--PERSONAL NAME
Personal name Wallendszus, Karl
Relator term author
9 (RLIN) 2210
700 10 - ADDED ENTRY--PERSONAL NAME
Personal name Brenner, Susanne
Relator term author
9 (RLIN) 2211
700 10 - ADDED ENTRY--PERSONAL NAME
Personal name Cheung, Alfred K.
Relator term author
9 (RLIN) 2212
700 10 - ADDED ENTRY--PERSONAL NAME
Personal name Liu, Zhi-Hong
Relator term author
9 (RLIN) 2213
700 10 - ADDED ENTRY--PERSONAL NAME
Personal name Li, Jing
Relator term author
9 (RLIN) 2214
700 10 - ADDED ENTRY--PERSONAL NAME
Personal name Hooi, Lai Seong
Relator term author
9 (RLIN) 2215
700 10 - ADDED ENTRY--PERSONAL NAME
Personal name Liu, Wen
Relator term author
9 (RLIN) 2216
700 10 - ADDED ENTRY--PERSONAL NAME
Personal name Kadowaki, Takashi
Relator term author
9 (RLIN) 2217
700 10 - ADDED ENTRY--PERSONAL NAME
Personal name Nangaku, Masaomi
Relator term author
9 (RLIN) 2218
700 10 - ADDED ENTRY--PERSONAL NAME
Personal name Levin, Adeera
Relator term author
9 (RLIN) 2219
700 10 - ADDED ENTRY--PERSONAL NAME
Personal name Cherney, David
Relator term author
9 (RLIN) 2220
700 10 - ADDED ENTRY--PERSONAL NAME
Personal name Maggioni, Aldo P.
Relator term author
9 (RLIN) 2221
700 10 - ADDED ENTRY--PERSONAL NAME
Personal name Pontremoli, Roberto
Relator term author
9 (RLIN) 2222
700 10 - ADDED ENTRY--PERSONAL NAME
Personal name Deo, Rajat
Relator term author
9 (RLIN) 2223
700 10 - ADDED ENTRY--PERSONAL NAME
Personal name Goto, Shinya
Relator term author
9 (RLIN) 2224
700 10 - ADDED ENTRY--PERSONAL NAME
Personal name Rossello, Xavier
Relator term author
9 (RLIN) 2225
700 10 - ADDED ENTRY--PERSONAL NAME
Personal name Tuttle, Katherine R.
Relator term author
9 (RLIN) 2226
700 10 - ADDED ENTRY--PERSONAL NAME
Personal name Steubl, Dominik
Relator term author
9 (RLIN) 2227
700 10 - ADDED ENTRY--PERSONAL NAME
Personal name Petrini, Michaela
Relator term author
9 (RLIN) 2228
700 10 - ADDED ENTRY--PERSONAL NAME
Personal name Massey, Dan
Relator term author
9 (RLIN) 2229
700 10 - ADDED ENTRY--PERSONAL NAME
Personal name Eilbracht, Jens
Relator term author
9 (RLIN) 2230
700 10 - ADDED ENTRY--PERSONAL NAME
Personal name Brueckmann, Martina
Relator term author
9 (RLIN) 2231
700 10 - ADDED ENTRY--PERSONAL NAME
Personal name Landray, Martin J.
Relator term author
9 (RLIN) 2232
700 10 - ADDED ENTRY--PERSONAL NAME
Personal name Baigent, Colin
Relator term author
9 (RLIN) 2233
700 10 - ADDED ENTRY--PERSONAL NAME
Personal name Haynes, Richard
Relator term author
9 (RLIN) 2234
786 0# - DATA SOURCE ENTRY
Note N Engl J Med
856 41 - ELECTRONIC LOCATION AND ACCESS
Uniform Resource Identifier <a href="http://dx.doi.org/10.1056/NEJMoa2204233">http://dx.doi.org/10.1056/NEJMoa2204233</a>
Public note Connect to this object online.

No items available.