JOM KITA KE POLITEKNIK

Acute BAF perturbation causes immediate changes in chromatin accessibility (Record no. 907)

MARC details
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Personal name Schick, Sandra
Relator term author
9 (RLIN) 2358
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Title Acute BAF perturbation causes immediate changes in chromatin accessibility
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Date of publication, distribution, etc. 2021-03-01.
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General note /pmc/articles/PMC7614082/
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General note /pubmed/33558760
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Summary, etc. Cancer-associated loss-of-function mutations in genes coding for subunits of the BRG1/BRM associated factor (BAF) chromatin remodeling complexes(1-8) often cause drastic chromatin accessibility changes, especially in important regulatory regions(9-19). However, it remains unknown how these changes are established over time (e.g. immediate consequences or long-term adaptations), and whether they are causative for intra-complex synthetic lethalities abrogating the formation or activity of BAF complexes(9,20-24). Here, we use the dTAG system to induce acute degradation of BAF subunits and show that chromatin alterations are established faster than the duration of one cell cycle. Using a pharmacological inhibitor and a chemical degrader of the BAF complex ATPase subunits(25,26), we show that maintaining genome accessibility requires constant ATP-dependent remodeling. Completely abolishing BAF complex function by acute degradation of a synthetic lethal subunit in a paralog-deficient background results in a near-complete loss of chromatin accessibility at BAF-controlled sites, especially at super-enhancers, providing a mechanism for intra-complex synthetic lethalities.
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Terms governing use and reproduction
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Terms governing use and reproduction http://www.nature.com/authors/editorial_policies/license.html#termsUsers may view, print, copy, and download text and data-mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use: http://www.nature.com/authors/editorial_policies/license.html#terms
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Language note en
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Topical term or geographic name as entry element Article
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Genre/form data or focus term Text
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Personal name Grosche, Sarah
Relator term author
9 (RLIN) 2359
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Personal name Kohl, Katharina Eva
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9 (RLIN) 2360
700 10 - ADDED ENTRY--PERSONAL NAME
Personal name Drpic, Danica
Relator term author
9 (RLIN) 2361
700 10 - ADDED ENTRY--PERSONAL NAME
Personal name Jaeger, Martin G.
Relator term author
9 (RLIN) 2362
700 10 - ADDED ENTRY--PERSONAL NAME
Personal name Marella, Nara C.
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9 (RLIN) 2363
700 10 - ADDED ENTRY--PERSONAL NAME
Personal name Imrichova, Hana
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9 (RLIN) 2364
700 10 - ADDED ENTRY--PERSONAL NAME
Personal name Lin, Jung-Ming G.
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9 (RLIN) 2365
700 10 - ADDED ENTRY--PERSONAL NAME
Personal name Hofstätter, Gerald
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9 (RLIN) 2366
700 10 - ADDED ENTRY--PERSONAL NAME
Personal name Schuster, Michael
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9 (RLIN) 2367
700 10 - ADDED ENTRY--PERSONAL NAME
Personal name Rendeiro, André F.
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9 (RLIN) 2368
700 10 - ADDED ENTRY--PERSONAL NAME
Personal name Koren, Anna
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9 (RLIN) 2369
700 10 - ADDED ENTRY--PERSONAL NAME
Personal name Petronczki, Mark
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9 (RLIN) 2370
700 10 - ADDED ENTRY--PERSONAL NAME
Personal name Bock, Christoph
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9 (RLIN) 2371
700 10 - ADDED ENTRY--PERSONAL NAME
Personal name Müller, André C.
Relator term author
9 (RLIN) 2372
700 10 - ADDED ENTRY--PERSONAL NAME
Personal name Winter, Georg E.
Relator term author
9 (RLIN) 2373
700 10 - ADDED ENTRY--PERSONAL NAME
Personal name Kubicek, Stefan
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9 (RLIN) 2374
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Note Nat Genet
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Uniform Resource Identifier <a href="http://dx.doi.org/10.1038/s41588-021-00777-3">http://dx.doi.org/10.1038/s41588-021-00777-3</a>
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