JOM KITA KE POLITEKNIK

Identification of aceNKPs, a committed common progenitor population of the ILC1 and NK cell continuum (Record no. 917)

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Personal name Rodriguez-Rodriguez, Noe
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Title Identification of aceNKPs, a committed common progenitor population of the ILC1 and NK cell continuum
260 ## - PUBLICATION, DISTRIBUTION, ETC.
Name of publisher, distributor, etc. National Academy of Sciences,
Date of publication, distribution, etc. 2022-11-29.
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General note /pmc/articles/PMC7614094/
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General note /pubmed/36442116
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Summary, etc. The development of innate lymphoid cell (ILC) transcription factor reporter mice has shown a previously unexpected complexity in ILC hematopoiesis. Using novel polychromic mice to achieve higher phenotypic resolution, we have characterized bone marrow progenitors that are committed to the group 1 ILC lineage. These common ILC1/NK cell progenitors (ILC1/NKP), which we call "aceNKPs", are defined as lineage(-)Id2(+)IL-7Rα(+)CD25(-)α4β7(-)NKG2A/C/E(+)Bcl11b(-). In vitro, aceNKPs differentiate into group 1 ILCs, including NK-like cells that express Eomes without the requirement for IL-15, and produce IFN-γ and perforin upon IL-15 stimulation. Following reconstitution of Rag2(-/-)Il2rg(-/-) hosts, aceNKPs give rise to a spectrum of mature ILC1/NK cells (regardless of their tissue location) that cannot be clearly segregated into the traditional ILC1 and NK subsets, suggesting that group 1 ILCs constitute a dynamic continuum of ILCs that can develop from a common progenitor. In addition, aceNKP-derived ILC1/NK cells effectively ameliorate tumor burden in a model of lung metastasis, where they acquired a cytotoxic NK cell phenotype. Our results identify the primary ILC1/NK progenitor that lacks ILC2 or ILC3 potential and is strictly committed to ILC1/NK cell production irrespective of tissue homing.
540 ## - TERMS GOVERNING USE AND REPRODUCTION NOTE
Terms governing use and reproduction Copyright © 2022 the Author(s). Published by PNAS.
540 ## - TERMS GOVERNING USE AND REPRODUCTION NOTE
Terms governing use and reproduction https://creativecommons.org/licenses/by/4.0/This open access article is distributed under Creative Commons Attribution License 4.0 (CC BY) (https://creativecommons.org/licenses/by/4.0/) .
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Language note en
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Topical term or geographic name as entry element Biological Sciences
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Genre/form data or focus term Text
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700 10 - ADDED ENTRY--PERSONAL NAME
Personal name Clark, Paula A.
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9 (RLIN) 1961
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Personal name Gogoi, Mayuri
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700 10 - ADDED ENTRY--PERSONAL NAME
Personal name Ferreira, Ana C. F.
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9 (RLIN) 1959
700 10 - ADDED ENTRY--PERSONAL NAME
Personal name Kerscher, Bernhard
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9 (RLIN) 2445
700 10 - ADDED ENTRY--PERSONAL NAME
Personal name Crisp, Alastair
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9 (RLIN) 1964
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Personal name Jolin, Helen E.
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9 (RLIN) 1965
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Personal name Murphy, Jane E.
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9 (RLIN) 2446
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Personal name Sivasubramaniam, Meera
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9 (RLIN) 1962
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Personal name Pedro, Luisa
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9 (RLIN) 2447
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Personal name Walker, Jennifer A.
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9 (RLIN) 2448
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Personal name Heycock, Morgan W. D.
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9 (RLIN) 1963
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Personal name Shields, Jacqueline D.
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9 (RLIN) 2449
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Personal name Barlow, Jillian L.
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9 (RLIN) 2450
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Personal name McKenzie, Andrew N. J.
Relator term author
9 (RLIN) 1968
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Note Proc Natl Acad Sci U S A
856 41 - ELECTRONIC LOCATION AND ACCESS
Uniform Resource Identifier <a href="http://dx.doi.org/10.1073/pnas.2203454119">http://dx.doi.org/10.1073/pnas.2203454119</a>
Public note Connect to this object online.

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