Evoked Resonant Neural Activity in subthalamic local field potentials reflects basal ganglia network dynamics (Record no. 944)
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042 ## - AUTHENTICATION CODE | |
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Authentication code | dc |
100 10 - MAIN ENTRY--PERSONAL NAME | |
Personal name | Wiest, Christoph |
Relator term | author |
9 (RLIN) | 2669 |
245 00 - TITLE STATEMENT | |
Title | Evoked Resonant Neural Activity in subthalamic local field potentials reflects basal ganglia network dynamics |
260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
Date of publication, distribution, etc. | 2023-03. |
500 ## - GENERAL NOTE | |
General note | /pmc/articles/PMC7614125/ |
500 ## - GENERAL NOTE | |
General note | /pubmed/36706929 |
520 ## - SUMMARY, ETC. | |
Summary, etc. | Evoked resonant neural activity (ERNA) is induced by subthalamic deep brain stimulation (DBS) and was recently suggested as a marker of lead placement and contact selection in Parkinson's disease. Yet, its underlying mechanisms and how it is modulated by stimulation parameters are unclear. Here, we recorded local field potentials from 27 Parkinson's disease patients, while leads were externalised to scrutinise the ERNA. First, we show that ERNA in the time series waveform and spectrogram likely represent the same activity, which was contested before. Second, our results show that the ERNA has fast and slow dynamics during stimulation, consistent with the synaptic failure hypothesis. Third, we show that ERNA parameters are modulated by different DBS frequencies, intensities, medication states and stimulation modes (continuous DBS vs. adaptive DBS). These results suggest the ERNA might prove useful as a predictor of the best DBS frequency and lowest effective intensity in addition to contact selection. Changes with levodopa and DBS mode suggest that the ERNA may indicate the state of the cortico-basal ganglia circuit making it a putative biomarker to track clinical state in adaptive DBS. |
540 ## - TERMS GOVERNING USE AND REPRODUCTION NOTE | |
Terms governing use and reproduction | |
540 ## - TERMS GOVERNING USE AND REPRODUCTION NOTE | |
Terms governing use and reproduction | https://creativecommons.org/licenses/by/4.0/This work is licensed under a CC BY 4.0 (https://creativecommons.org/licenses/by/4.0/) International license. |
546 ## - LANGUAGE NOTE | |
Language note | en |
690 ## - LOCAL SUBJECT ADDED ENTRY--TOPICAL TERM (OCLC, RLIN) | |
Topical term or geographic name as entry element | Article |
655 7# - INDEX TERM--GENRE/FORM | |
Genre/form data or focus term | Text |
Source of term | local |
700 10 - ADDED ENTRY--PERSONAL NAME | |
Personal name | He, Shenghong |
Relator term | author |
9 (RLIN) | 2670 |
700 10 - ADDED ENTRY--PERSONAL NAME | |
Personal name | Duchet, Benoit |
Relator term | author |
9 (RLIN) | 2671 |
700 10 - ADDED ENTRY--PERSONAL NAME | |
Personal name | Pogosyan, Alek |
Relator term | author |
700 10 - ADDED ENTRY--PERSONAL NAME | |
Personal name | Benjaber, Moaad |
Relator term | author |
9 (RLIN) | 2673 |
700 10 - ADDED ENTRY--PERSONAL NAME | |
Personal name | Denison, Timothy |
Relator term | author |
9 (RLIN) | 2674 |
700 10 - ADDED ENTRY--PERSONAL NAME | |
Personal name | Hasegawa, Harutomo |
Relator term | author |
9 (RLIN) | 2675 |
700 10 - ADDED ENTRY--PERSONAL NAME | |
Personal name | Ashkan, Keyoumars |
Relator term | author |
9 (RLIN) | 2676 |
700 10 - ADDED ENTRY--PERSONAL NAME | |
Personal name | Baig, Fahd |
Relator term | author |
9 (RLIN) | 2677 |
700 10 - ADDED ENTRY--PERSONAL NAME | |
Personal name | Bertaina, Ilaria |
Relator term | author |
9 (RLIN) | 2678 |
700 10 - ADDED ENTRY--PERSONAL NAME | |
Personal name | Morgante, Francesca |
Relator term | author |
9 (RLIN) | 2679 |
700 10 - ADDED ENTRY--PERSONAL NAME | |
Personal name | Pereira, Erlick A. |
Relator term | author |
9 (RLIN) | 2680 |
700 10 - ADDED ENTRY--PERSONAL NAME | |
Personal name | Torrecillos, Flavie |
Relator term | author |
700 10 - ADDED ENTRY--PERSONAL NAME | |
Personal name | Tan, Huiling |
Relator term | author |
786 0# - DATA SOURCE ENTRY | |
Note | Neurobiol Dis |
856 41 - ELECTRONIC LOCATION AND ACCESS | |
Uniform Resource Identifier | <a href="http://dx.doi.org/10.1016/j.nbd.2023.106019">http://dx.doi.org/10.1016/j.nbd.2023.106019</a> |
Public note | Connect to this object online. |
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