Combining Multimodal Biomarkers to Guide Deep Brain Stimulation Programming in Parkinson Disease (Record no. 959)
[ view plain ]
042 ## - AUTHENTICATION CODE | |
---|---|
Authentication code | dc |
100 10 - MAIN ENTRY--PERSONAL NAME | |
Personal name | Shah, Ashesh |
Relator term | author |
9 (RLIN) | 2791 |
245 00 - TITLE STATEMENT | |
Title | Combining Multimodal Biomarkers to Guide Deep Brain Stimulation Programming in Parkinson Disease |
260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
Date of publication, distribution, etc. | 2022-02-23. |
500 ## - GENERAL NOTE | |
General note | /pmc/articles/PMC7614142/ |
500 ## - GENERAL NOTE | |
General note | /pubmed/35219571 |
520 ## - SUMMARY, ETC. | |
Summary, etc. | BACKGROUND: Deep brain stimulation (DBS) programming of multicontact DBS leads relies on a very time-consuming manual screening procedure, and strategies to speed up this process are needed. Beta activity in subthalamic nucleus (STN) local field potentials (LFP) has been suggested as a promising marker to index optimal stimulation contacts in patients with Parkinson disease. OBJECTIVE: In this study, we investigate the advantage of algorithmic selection and combination of multiple resting and movement state features from STN LFPs and imaging markers to predict three relevant clinical DBS parameters (clinical efficacy, therapeutic window, side-effect threshold). MATERIALS AND METHODS: STN LFPs were recorded at rest and during voluntary movements from multicontact DBS leads in 27 hemispheres. Resting- and movement-state features from multiple frequency bands (alpha, low beta, high beta, gamma, fast gamma, high frequency oscillations [HFO]) were used to predict the clinical outcome parameters. Subanalyses included an anatomical stimulation sweet spot as an additional feature. RESULTS: Both resting- and movement-state features contributed to the prediction, with resting (fast) gamma activity, resting/ movement-modulated beta activity, and movement-modulated HFO being most predictive. With the proposed algorithm, the best stimulation contact for the three clinical outcome parameters can be identified with a probability of almost 90% after considering half of the DBS lead contacts, and it outperforms the use of beta activity as single marker. The combination of electrophysiological and imaging markers can further improve the prediction. CONCLUSION: LFP-guided DBS programming based on algorithmic selection and combination of multiple electrophysiological and imaging markers can be an efficient approach to improve the clinical routine and outcome of DBS patients. |
540 ## - TERMS GOVERNING USE AND REPRODUCTION NOTE | |
Terms governing use and reproduction | |
540 ## - TERMS GOVERNING USE AND REPRODUCTION NOTE | |
Terms governing use and reproduction | https://creativecommons.org/licenses/by/4.0/This is an open access article under the CC BY license (https://creativecommons.org/licenses/by/4.0/). |
546 ## - LANGUAGE NOTE | |
Language note | en |
690 ## - LOCAL SUBJECT ADDED ENTRY--TOPICAL TERM (OCLC, RLIN) | |
Topical term or geographic name as entry element | Article |
655 7# - INDEX TERM--GENRE/FORM | |
Genre/form data or focus term | Text |
Source of term | local |
700 10 - ADDED ENTRY--PERSONAL NAME | |
Personal name | Nguyen, Thuy-Anh Khoa |
Relator term | author |
9 (RLIN) | 2792 |
700 10 - ADDED ENTRY--PERSONAL NAME | |
Personal name | Peterman, Katrin |
Relator term | author |
9 (RLIN) | 2793 |
700 10 - ADDED ENTRY--PERSONAL NAME | |
Personal name | Khawaldeh, Saed |
Relator term | author |
9 (RLIN) | 2794 |
700 10 - ADDED ENTRY--PERSONAL NAME | |
Personal name | Debove, Ines |
Relator term | author |
9 (RLIN) | 2795 |
700 10 - ADDED ENTRY--PERSONAL NAME | |
Personal name | Shah, Syed Ahmar |
Relator term | author |
9 (RLIN) | 2796 |
700 10 - ADDED ENTRY--PERSONAL NAME | |
Personal name | Torrecillos, Flavie |
Relator term | author |
700 10 - ADDED ENTRY--PERSONAL NAME | |
Personal name | Tan, Huiling |
Relator term | author |
700 10 - ADDED ENTRY--PERSONAL NAME | |
Personal name | Pogosyan, Alek |
Relator term | author |
700 10 - ADDED ENTRY--PERSONAL NAME | |
Personal name | Lachenmayer, Martin Lenard |
Relator term | author |
9 (RLIN) | 2800 |
700 10 - ADDED ENTRY--PERSONAL NAME | |
Personal name | Michelis, Joan |
Relator term | author |
9 (RLIN) | 2801 |
700 10 - ADDED ENTRY--PERSONAL NAME | |
Personal name | Brown, Peter |
Relator term | author |
9 (RLIN) | 2802 |
700 10 - ADDED ENTRY--PERSONAL NAME | |
Personal name | Pollo, Claudio |
Relator term | author |
9 (RLIN) | 2803 |
700 10 - ADDED ENTRY--PERSONAL NAME | |
Personal name | Krack, Paul |
Relator term | author |
9 (RLIN) | 2804 |
700 10 - ADDED ENTRY--PERSONAL NAME | |
Personal name | Nowacki, Andreas |
Relator term | author |
9 (RLIN) | 2805 |
700 10 - ADDED ENTRY--PERSONAL NAME | |
Personal name | Tinkhauser, Gerd |
Relator term | author |
9 (RLIN) | 2806 |
786 0# - DATA SOURCE ENTRY | |
Note | Neuromodulation |
856 41 - ELECTRONIC LOCATION AND ACCESS | |
Uniform Resource Identifier | <a href="http://dx.doi.org/10.1016/j.neurom.2022.01.017">http://dx.doi.org/10.1016/j.neurom.2022.01.017</a> |
Public note | Connect to this object online. |
No items available.