JOM KITA KE POLITEKNIK

Advances in methods to analyse cardiolipin and their clinical applications (Record no. 963)

MARC details
042 ## - AUTHENTICATION CODE
Authentication code dc
100 10 - MAIN ENTRY--PERSONAL NAME
Personal name Bautista, Javier S.
Relator term author
9 (RLIN) 2814
245 00 - TITLE STATEMENT
Title Advances in methods to analyse cardiolipin and their clinical applications
260 ## - PUBLICATION, DISTRIBUTION, ETC.
Date of publication, distribution, etc. 2022-12.
500 ## - GENERAL NOTE
General note /pmc/articles/PMC7614147/
500 ## - GENERAL NOTE
General note /pubmed/36751553
520 ## - SUMMARY, ETC.
Summary, etc. Cardiolipin (CL) is a mitochondria-exclusive phospholipid, primarily localised within the inner mitochondrial membrane, that plays an essential role in mitochondrial architecture and function. Aberrant CL content, structure, and localisation have all been linked to impaired mitochondrial activity and are observed in the pathophysiology of cancer and neurological, cardiovascular, and metabolic disorders. The detection, quantification, and localisation of CL species is a valuable tool to investigate mitochondrial dysfunction and the pathophysiological mechanisms underpinning several human disorders. CL is measured using liquid chromatography, usually combined with mass spectrometry, mass spectrometry imaging, shotgun lipidomics, ion mobility spectrometry, fluorometry, and radiolabelling. This review summarises available methods to analyse CL, with a particular focus on modern mass spectrometry, and evaluates their advantages and limitations. We provide guidance aimed at selecting the most appropriate technique, or combination of techniques, when analysing CL in different model systems, and highlight the clinical contexts in which measuring CL is relevant.
540 ## - TERMS GOVERNING USE AND REPRODUCTION NOTE
Terms governing use and reproduction
540 ## - TERMS GOVERNING USE AND REPRODUCTION NOTE
Terms governing use and reproduction https://creativecommons.org/licenses/by/4.0/This work is licensed under a CC BY 4.0 (https://creativecommons.org/licenses/by/4.0/) International license.
546 ## - LANGUAGE NOTE
Language note en
690 ## - LOCAL SUBJECT ADDED ENTRY--TOPICAL TERM (OCLC, RLIN)
Topical term or geographic name as entry element Article
655 7# - INDEX TERM--GENRE/FORM
Genre/form data or focus term Text
Source of term local
700 10 - ADDED ENTRY--PERSONAL NAME
Personal name Falabella, Micol
Relator term author
9 (RLIN) 2815
700 10 - ADDED ENTRY--PERSONAL NAME
Personal name Flannery, Padraig J.
Relator term author
9 (RLIN) 2816
700 10 - ADDED ENTRY--PERSONAL NAME
Personal name Hanna, Michael G.
Relator term author
9 (RLIN) 2817
700 10 - ADDED ENTRY--PERSONAL NAME
Personal name Heales, Simon J.R.
Relator term author
9 (RLIN) 2818
700 10 - ADDED ENTRY--PERSONAL NAME
Personal name Pope, Simon A.S.
Relator term author
9 (RLIN) 2819
700 10 - ADDED ENTRY--PERSONAL NAME
Personal name Pitceathly, Robert D.S.
Relator term author
9 (RLIN) 2820
786 0# - DATA SOURCE ENTRY
Note Trends Analyt Chem
856 41 - ELECTRONIC LOCATION AND ACCESS
Uniform Resource Identifier <a href="http://dx.doi.org/10.1016/j.trac.2022.116808">http://dx.doi.org/10.1016/j.trac.2022.116808</a>
Public note Connect to this object online.

No items available.