JOM KITA KE POLITEKNIK

Cellular senescence is immunogenic and promotes anti-tumor immunity (Record no. 967)

MARC details
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Personal name Marin, Ines
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9 (RLIN) 2841
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Title Cellular senescence is immunogenic and promotes anti-tumor immunity
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Date of publication, distribution, etc. 2022-10-27.
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General note /pmc/articles/PMC7614152/
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General note /pubmed/36302218
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Summary, etc. Cellular senescence is a stress response that activates innate immune cells, but little is known about its interplay with the adaptive immune system. Here, we show that senescent cells combine several features that render them highly efficient in activating dendritic cells (DCs) and antigen-specific CD8 T cells. This includes the release of alarmins, activation of interferon signaling, enhanced MHC class I machinery, and presentation of senescence-specific self-peptides that can activate CD8 T cells. In the context of cancer, immunization with senescent cancer cells elicits strong anti-tumor protection mediated by DCs and CD8 T cells. Interestingly, this protection is superior to immunization with cancer cells undergoing immunogenic cell death. Finally, the induction of senescence in human primary cancer cells also augments their ability to activate autologous antigen-specific tumor-infiltrating CD8 lymphocytes. Our study indicates that senescent cancer cells can be exploited to develop efficient and protective CD8-dependent anti-tumor immune responses.
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Terms governing use and reproduction
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Language note en
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Topical term or geographic name as entry element Article
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Genre/form data or focus term Text
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Personal name Boix, Olga
Relator term author
9 (RLIN) 2842
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Personal name Garcia-Garijo, Andrea
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9 (RLIN) 2843
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Personal name Sirois, Isabelle
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9 (RLIN) 2844
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Personal name Caballe, Adrià
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9 (RLIN) 2845
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Personal name Zarzuela, Eduardo
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9 (RLIN) 2846
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Personal name Ruano, Irene
Relator term author
9 (RLIN) 2847
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Personal name Attolini, Camille Stephan-Otto
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9 (RLIN) 2848
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Personal name Prats, Neus
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9 (RLIN) 2849
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Personal name López-Domínguez, José A
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9 (RLIN) 2850
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Personal name Kovatcheva, Marta
Relator term author
9 (RLIN) 2851
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Personal name Garralda, Elena
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9 (RLIN) 2852
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Personal name Muñoz, Javier
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9 (RLIN) 2853
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Personal name Caron, Etienne
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9 (RLIN) 2854
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Personal name Abad, María
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9 (RLIN) 2855
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Personal name Gros, Alena
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9 (RLIN) 2856
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Personal name Pietrocola, Federico
Relator term author
9 (RLIN) 2857
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Personal name Serrano, Manuel
Relator term author
9 (RLIN) 2858
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Note Cancer Discov
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Uniform Resource Identifier <a href="http://dx.doi.org/10.1158/2159-8290.CD-22-0523">http://dx.doi.org/10.1158/2159-8290.CD-22-0523</a>
Public note Connect to this object online.

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