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Time to re-evaluate the risks and benefits of valproate and a call for action

By: Contributor(s): Publication details: 2022-12.Subject(s): Genre/Form: Online resources: Summary: Valproate is widely used in psychiatry and neurology, including off-label use. Here we consider its potential benefits and risks, particularly in women of child-bearing potential, and the evidence that clinical guidelines are adhered to. Finally, we consider the implications for clinical practice and research into its efficacy in off-label indications.
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/pmc/articles/PMC7613842/

/pubmed/35795925

Valproate is widely used in psychiatry and neurology, including off-label use. Here we consider its potential benefits and risks, particularly in women of child-bearing potential, and the evidence that clinical guidelines are adhered to. Finally, we consider the implications for clinical practice and research into its efficacy in off-label indications.

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