TY  - BOOK
AU  - Plomin,Robert
AU  - Gidziela,Agnieszka
AU  - Malanchini,Margherita
AU  - von Stumm,Sophie
TI  - Gene-environment interaction using polygenic scores: Do polygenic  scores for psychopathology moderate predictions from environmental risk to  behavior problems?
PY  - 2022///-09-23
KW  - Text
KW  - local
N1  - /pmc/articles/PMC7613991; /pubmed/36148872
N2  - The DNA revolution has energized research on interactions between genes and environments (GxE) by creating indices of G (polygenic scores) that are powerful predictors of behavioral traits. Here, we test the extent to which polygenic scores for ADHD and neuroticism moderate associations between parent reports of their children's environmental risk (E) at ages 3 and 4 and teacher ratings of behavior problems (hyperactivity/inattention, conduct problems, emotional symptoms, and peer relationship problems) at ages 7, 9 and 12. The sampling frame included up to 6687 twins from the Twins Early Development Study (TEDS). Our analyses focused on relative effect sizes of G, E and GxE in predicting behavior problems. G, E and GxE predicted up to 2%, 2% and 0.4%, respectively, of the variance in externalizing behavior problems (hyperactivity/inattention and conduct problems) across ages 7, 9 and 12, with no clear developmental trends. G and E predictions of emotional symptoms and peer relationship problems were weaker. A quarter (12 of 48) of our tests of GxE were nominally significant (p =.05). Increasing the predictive power of G and E would enhance the search for GxE
UR  - http://dx.doi.org/10.1017/S0954579422000931
ER  -