TY  - BOOK
AU  - Benjamin,Mercilena
AU  - Malakar,Pushkar
AU  - Sinha,Rohit Anthony
AU  - Nasser,Mohd Wasim
AU  - Batra,Surinder K.
AU  - Siddiqui,Jawed Akhtar
AU  - Chakravarti,Bandana
TI  - Molecular signaling network and therapeutic developments in breast cancer brain metastasis
PY  - 2023///-07
KW  - Text
KW  - local
N1  - /pmc/articles/PMC7613958; /pubmed/36536947
N2  - Breast cancer (BC) is one of the most frequently diagnosed cancers in women worldwide. It has surpassed lung cancer as the leading cause of cancer-related death. Breast cancer brain metastasis (BCBM) is becoming a major clinical concern that is commonly associated with ER-ve and HER2+ve subtypes of BC patients. Metastatic lesions in the brain originate when the cancer cells detach from a primary breast tumor and establish metastatic lesions and infiltrate near and distant organs via systemic blood circulation by traversing the BBB. The colonization of BC cells in the brain involves a complex interplay in the tumor microenvironment (TME), metastatic cells, and brain cells like endothelial cells, microglia, and astrocytes. BCBM is a significant cause of morbidity and mortality and presents a challenge to developing successful cancer therapy. In this review, we discuss the molecular mechanism of BCBM and novel therapeutic strategies for patients with brain metastatic BC
UR  - http://dx.doi.org/10.1016/j.adcanc.2022.100079
ER  -