Fetal liver hematopoiesis revisited: a precast hierarchy
- 2022-10.
/pmc/articles/PMC7614020/ /pubmed/36605232
Late fetal liver hematopoiesis was thought to primarily rely on hematopoietic stem cells (HSCs). Using new genetic-tracing tools, a study shows that EVI1-positive HSCs mainly undergo expansion in the fetal liver, while differentiated blood cell production depends on HSC-independent intermediate hematopoietic progenitors.