000			04077 am a22003013u 4500
042			_adc
100	1	0	_aDauer, Lawrence T. _eauthor _9642
700	1	0	_aWoods, Meghan _eauthor _9643
700	1	0	_aMiodownik, Daniel _eauthor _9644
700	1	0	_aSerencsits, Brian _eauthor _9645
700	1	0	_aQuinn, Brian _eauthor _9646
700	1	0	_aBellamy, Michael _eauthor _9647
700	1	0	_aYoder, Craig _eauthor _9648
700	1	0	_aLiang, Xiaolin _eauthor _9649
700	1	0	_aBoice, John D. _eauthor _9650
700	1	0	_aBernstein, Jonine _eauthor _9651
245	0	0	_aCohort Profile - MSK Radiation Workers: a Feasibility Study to Establish a Deceased Worker Sub-Cohort as part of a Multicenter Medical Radiation Worker Component in the Million Person Study of Low-Dose Radiation Health Effects
260			_c2022.
500			_a/pmc/articles/PMC7147486/
500			_a/pubmed/30810447
520			_aBACKGROUND: The National Council on Radiation Protection and Measurements (NCRP) is coordinating an expansive epidemiologic effort entitled the Million Person Study of Low-Dose Radiation Health Effects (MPS). Medical workers constitute the largest occupational radiation exposed group whose doses are typically received gradually over time. METHODS: A unique opportunity exists to establish an Institutional Review Board/Privacy Board (IRB/PB) approved, retrospective feasibility sub-cohort of diseased Memorial Sloan Kettering Cancer Center (MSK) medical radiation workers to reconstruct occupational/work history, estimate organ-specific radiation absorbed doses, and review existing publicly available records for mortality from cancer (including leukemia) and other diseases. Special emphasis will be placed on dose reconstruction approaches as a means to provide valid organ dose estimates that are as accurate and precise as possible based on the available data, and to allow proper evaluation of accompanying uncertainties. Such a study that includes validated dose measurements and information on radiation exposure conditions would significantly reduce dose uncertainties and provided greatly improved information on chronic low-dose risks. RESULTS: The feasibility sub-cohort will include deceased radiation workers from MSK who worked during the nearly seventy-year timeframe from 1946 through 2010 and were provided individual personal radiation dosimetry monitors. A feasibility assessment focused on obtaining records for about 25-30,000 workers, with over 124,000 annual doses, including personnel/work histories, specific dosimetry data, and appropriate information for epidemiologic mortality tracing will be conducted. MSK radiation dosimetry measurements have followed stringent protocols complying with strict worker protection standards in order to provide accurate dose information for radiation workers that include detailed records of work practices (including specific task exposure conditions, radiation type, energy, geometry, personal protective equipment usage, badge position, and missed doses), as well as recorded measurements. These dose measurements have been ascertained through a variety of techniques that have evolved over the years, from film badges to thermoluminescent dosimetry technology to optically stimulated luminescent methodologies. It is expected that individual total doses for the sub-cohort will have a broad range from <10 mSv to >=1000 mSv. CONCLUSIONS: MSK has pioneered the use of novel radiation diagnostic and therapeutic approaches over time (including initial work with x-rays, radium and radon), with workplace safety in mind, resulting in a variety of radiation worker exposure scenarios. The results of this feasibility sub-cohort of deceased radiation workers, and associated lessons learned may potentially be applied to an expanded multicenter study of about 170,000 medical radiation worker component of the MPS.
540			_a
546			_aen
690			_aArticle
655	7		_aText _2local
786	0		_nInt J Radiat Biol
856	4	1	_uhttp://dx.doi.org/10.1080/09553002.2019.1587194 _zConnect to this object online.
999			_c1288 _d1288